Evidence map›Paper›PMID 41155906›Full record

ReviewPharmaceutics2025

Development of a Novel Compound Effective Against Juvenile, Adult, and Drug-Resistant

Sevan N Alwan, Alexander B Taylor, Stanton F McHardy, Michael D Cameron, Philip T LoVerde

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sevan N AlwanDepartment of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0001-8701-4859
Alexander B TaylorDepartment of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0003-3517-6033
Stanton F McHardyCenter for Innovative Drug Discovery, Department of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0003-0070-4924
Michael D CameronDepartment of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL 33458, USA.ORCID 0000-0003-3154-4775
Philip T LoVerdeDepartment of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX 78229, USA.

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUM1TR004538 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ROBERT A CLARK, Kenneth M Hargreaves · 2023 to 2026
$22.3M
Preclinical Testing of Potential Next-generation Antischistosomal CompoundsR56AI180213 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ALWAN, SEVAN NAJM, CAMERON, MICHAEL DARIN · 2024 to 2024
$810k
Upgrade of a Core Laboratory Macromolecular X-ray Diffraction SystemS10OD030374 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI TAYLOR, ALEXANDER B · 2021 to 2021
$439k
NCATS NIH HHS UM1 TR004538NCI NIH HHS P30 CA054174NIAID NIH HHS R56 AI180213NIH HHS S10 OD030374NIH NIAID 1R56AI180213-01A1Office of the Vice President for Research Internal Funding Programs UT Health San Antoni 174597-23092
6 · The paper itself

Abstract

Schistosomiasis, a neglected tropical disease affecting over 250 million people worldwide, relies on praziquantel (PZQ) as its sole treatment. However, PZQ has significant limitations, including inactivity against juvenile worms, inability to prevent reinfection, and emerging drug resistance. In this review, we outline the development of CIDD-0150303, a novel oxamniquine (OXA) derivative with pan-species and pan-stage activity against

Indexed as

drug discoverydrug resistanceoxamniquineSchistosoma

Identifiers

PMID41155906
PMCPMC12567056

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.