Evidence map›Paper›PMID 41155807›Full record

ReviewMedicina (Kaunas, Lithuania)2025

Current and Emerging Approaches in the Management of Severe Ocular Surface Disease.

Sandeep K Dhallu, Molly J Pritchard, David Y S Chau, Stewart B Kirton

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Freeze-Dried Extracts ofPreventive nutrition and food science · 2026
    Article
  2. Article
  3. Crosslinking of tarsal collagen as a hypothetical therapy for dry eye disease.Medical hypothesis, discovery & innovation ophthalmology journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sandeep K DhalluClinical Pharmaceutical and Biological Science, University of Hertfordshire, Hatfield AL10 9AB, UK.ORCID 0000-0001-5011-4469
Molly J PritchardDivision of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.ORCID 0009-0004-9403-3571
David Y S ChauDivision of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.ORCID 0000-0001-9200-6749
Stewart B KirtonClinical Pharmaceutical and Biological Science, University of Hertfordshire, Hatfield AL10 9AB, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ocular surface disorders such as dry eye disease are an increasingly encountered ophthalmic disorder, in which signs and symptoms can vary significantly from one patient to the next. Severe dry eye can be a challenge for the ophthalmic practitioner to manage. Contemporary management options are wide-ranging and include topical treatments, contact lenses, and surgical options. More recently, newer stem cell-based therapies have emerged, and early reports have shown promising outcomes. Meanwhile, other novel approaches, such as the eggshell membrane, are currently in development, and while no studies have yet reported on its use in ophthalmic applications, further developments in this area are expected. However, longer-term studies are needed in order to fully assess the safety and efficacy of these newer treatments. There are an increasing number of treatment options available for ocular surface disorders. This article provides an overview of some of the current treatment options that are available for severe ocular surface disorders, including dry eye disease, as well as insight into applications that are currently in development, which may show potential in the future.

Indexed as

Dry Eye SyndromesContact LensesHumansStem Cell Transplantationamnionbiomaterialseggshell membraneeyeophthalmologyregenerative medicine

Identifiers

PMID41155807
PMCPMC12566017

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.