Evidence map›Paper›PMID 41155646›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Resensitizing the Untreatable: Zidovudine and Polymyxin Combinations to Combat Pan-Drug-Resistant

Jan Naseer Kaur, Jack F Klem, Gebremedhin S Hailu, Nader N Nasief, Yang Liu, Allison Hanna, Albert Chen, Patricia Holden, Shivali Kapoor, Nicholas M Smith and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jan Naseer KaurUB Center of Infectious Diseases, University at Buffalo, Buffalo, NY 14214, USA.ORCID 0000-0002-4808-3904
Jack F KlemUB Center of Infectious Diseases, University at Buffalo, Buffalo, NY 14214, USA.
Gebremedhin S HailuUB Center of Infectious Diseases, University at Buffalo, Buffalo, NY 14214, USA.ORCID 0000-0001-8638-3214
Nader N NasiefUB Center of Infectious Diseases, University at Buffalo, Buffalo, NY 14214, USA.
Yang LiuUB Center of Infectious Diseases, University at Buffalo, Buffalo, NY 14214, USA.ORCID 0009-0008-7722-6389
Allison HannaJacobs School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA.
Albert ChenUB Center of Infectious Diseases, University at Buffalo, Buffalo, NY 14214, USA.
Patricia HoldenUB Center of Infectious Diseases, University at Buffalo, Buffalo, NY 14214, USA.
Shivali KapoorUB Center of Infectious Diseases, University at Buffalo, Buffalo, NY 14214, USA.
Nicholas M SmithUB Center of Infectious Diseases, University at Buffalo, Buffalo, NY 14214, USA.ORCID 0000-0002-0212-2787
Mark SuttonJacobs School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA.
Jian LiMonash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC 3800, Australia.
Brian T TsujiUB Center of Infectious Diseases, University at Buffalo, Buffalo, NY 14214, USA.

Funding

Novel Strategies for Antibiotic Combinations to Combat Gram-negative SuperbugsR01AI148560 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BULITTA, JURGEN BERND, TSUJI, BRIAN · 2020 to 2024
$3.9M
Novel Combination Therapies to Combat Hypermutable Carbapenem-Resistant P. aeruginosaR01AI165997 · NIAID · UNIVERSITY OF COLORADO DENVER · PI MARK D. SUTTON, Brian Tsuji · 2022 to 2026
$3.9M
Novel Biamyxins targeting multidrug resistant Gram-negative bacterial infectionsR01AI182297 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Yanan Zhao · 2024 to 2026
$2.4M
Pharmacokinetics and Pharmacodynamics of Mechanistically Aware Phage CocktailsR01AI177997 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Nicholas Michael Smith · 2024 to 2026
$2.2M
NIAID NIH HHS R01 AI148560NIAID NIH HHS R01 AI165997NIAID NIH HHS R01 AI177997NIAID NIH HHS R01 AI182297
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antimicrobial resistancecombination therapydrug repurposingKlebsiella pneumoniae

Identifiers

PMID41155646
PMCPMC12566730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.