ArticleInternational journal of molecular sciences2025
Transcriptomic Profiling of the Tumor Microenvironment in High-Grade Serous Carcinoma: A Pilot Study of Morphologic and Molecular Distinctions Between Classic and SET Patterns.
Riccardo Giannini, Francesco Bartoli, Katia De Ieso, Tiziano Camacci, Andrea Bertolucci, Lorenzo Piccini, Erion Rreka, Duccio Volterrani, Federica Gemignani, Stefano Landi and 3 more
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In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Riccardo GianniniDipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, Università di Pisa, 56126 Pisa, Italy.ORCID 0000-0001-9740-0219 Francesco BartoliDipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, 56126 Pisa, Italy.ORCID 0000-0002-2702-3259 Katia De IesoD.A.I. Oncologia, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy.
Tiziano CamacciD.A.I. Oncologia, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy.
Andrea BertolucciD.A.I. Chirurgia Generale e Urologia, U.O. Chirurgia Generale e Peritoneale SSN, Centro Clinico Chirurgia del Peritoneo SSN, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy.ORCID 0000-0002-6322-9799 Lorenzo PicciniD.A.I. Chirurgia Generale e Urologia, U.O. Chirurgia Generale e Peritoneale SSN, Centro Clinico Chirurgia del Peritoneo SSN, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy.
Erion RrekaD.A.I. Chirurgia Generale e Urologia, U.O. Chirurgia Generale e Peritoneale SSN, Centro Clinico Chirurgia del Peritoneo SSN, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy.
Duccio VolterraniDipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, 56126 Pisa, Italy.
Federica GemignaniDipartimento di Biologia, Università di Pisa, 56126 Pisa, Italy.
Clara UgoliniDipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, Università di Pisa, 56126 Pisa, Italy.
Piero Vincenzo LippolisD.A.I. Chirurgia Generale e Urologia, U.O. Chirurgia Generale e Peritoneale SSN, Centro Clinico Chirurgia del Peritoneo SSN, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy.ORCID 0009-0009-7424-4335 Pinuccia FavianaDipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, Università di Pisa, 56126 Pisa, Italy.ORCID 0000-0003-4283-1083 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
High-grade serous carcinoma (HGSC) of the ovary is characterized by two major histological patterns: a classic papillary/micropapillary architecture and a solid pseudo-endometrioid transitional (SET) variant. We investigated whether the distinct morphologic subtypes are underpinned by transcriptomic differences in the tumor microenvironment (TME). We profiled 21 HGSC tumors (7 SET, 14 classic) using a 770-gene NanoString PanCancer Progression panel. Differential expression analysis revealed ~20 genes with significantly different expression (>4-fold, adjusted
Indexed as
Cystadenocarcinoma, SerousGene Expression ProfilingOvarian NeoplasmsTranscriptomeTumor MicroenvironmentAgedBiomarkers, TumorEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedNeoplasm GradingPilot ProjectsBiomarkers, Tumorangiogenesisextracellular matrixhigh-grade serous carcinomaimmune signatureSET morphologytranscriptomicstumor microenvironment
Identifiers
PMID41155518
PMCPMC12563879
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