Evidence map›Paper›PMID 41155507›Full record

ArticleInternational journal of molecular sciences2025

Genetic Variants in

Balázs Sonkodi, Zsófia Flóra Nagy, Anikó Keller-Pintér, Péter Klivényi, Mária Judit Molnár, Márta Széll

Abstract read
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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Balázs SonkodiDepartment of Health Sciences and Sport Medicine, Hungarian University of Sports Science, 1124 Budapest, Hungary.ORCID 0000-0003-1267-1306
Zsófia Flóra NagyDepartment of Medical Genetics, Albert Szent-Györgyi Medical School, University of Szeged, 6720 Szeged, Hungary.ORCID 0000-0001-6476-1181
Anikó Keller-PintérDepartment of Biochemistry, Albert Szent-Györgyi Medical School, University of Szeged, 6720 Szeged, Hungary.ORCID 0000-0002-4105-8458
Péter KlivényiDepartment of Neurology, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, Hungary.ORCID 0000-0002-5389-3266
Mária Judit MolnárInstitute of Genomic Medicine and Rare Disorders, Semmelweis University, 1085 Budapest, Hungary.
Márta SzéllDepartment of Medical Genetics, Albert Szent-Györgyi Medical School, University of Szeged, 6720 Szeged, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a multisystem progressive neurodegenerative disease. A recent theory of ALS onsetting pathogenesis proposed that the initiating primary damage is an acquired irreversible intrafusal proprioceptive terminal PIEZO2 channelopathy with underlying genetic and environmental risk factors. This Piezo2 channelopathy may also disrupt the ultrafast proton-based oscillatory signaling to motor neurons through vesicular transporter 1 (VGLUT1) and to the hippocampus through VGLUT2. As a result, it may gradually degenerate motor neurons in which process K

Indexed as

Amyotrophic Lateral SclerosisChannelopathiesHeat Shock Transcription FactorsIon ChannelsKv1.2 Potassium ChannelAdultAgedFemaleGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiddle AgedHeat Shock Transcription FactorsIon ChannelsKv1.2 Potassium ChannelPIEZO2 protein, humanamyotrophic lateral sclerosischannelopathygenetic variantsPiezo2whole exome sequencing

Identifiers

PMID41155507
PMCPMC12563250

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.