Evidence map›Paper›PMID 41155494›Full record

ArticleInternational journal of molecular sciences2025

Are pNF-H, IL-6, BDNF, and NSP Reliable Biomarkers of Cognitive Function in Prostate Cancer Patients?

Alicja Popiołek, Bartosz Brzoszczyk, Alina Borkowska, Piotr Jarzemski, Mariusz Kozakiewicz, Adam Szelągowski, Maciej Bieliński

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alicja PopiołekDepartment of Clinical Neuropsychology, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 87-100 Toruń, Poland.ORCID 0000-0002-8872-6054
Bartosz BrzoszczykDepartment and Clinic of Urology, Jan Biziel University Hospital No. 2 in Bydgoszcz, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 87-100 Toruń, Poland.
Alina BorkowskaDepartment of Clinical Neuropsychology, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 87-100 Toruń, Poland.ORCID 0000-0001-7305-0242
Piotr JarzemskiDepartment and Clinic of Urology, Jan Biziel University Hospital No. 2 in Bydgoszcz, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 87-100 Toruń, Poland.
Mariusz KozakiewiczDepartment of Geriatrics, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 87-100 Toruń, Poland.ORCID 0000-0002-6988-3038
Adam SzelągowskiDepartment of Geriatrics, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 87-100 Toruń, Poland.
Maciej BielińskiDepartment of Clinical Neuropsychology, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 87-100 Toruń, Poland.ORCID 0000-0001-8345-7214

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive decline can result from various factors, including direct neurotoxic injury, brain tissue damage, inflammation, and disruptions in coagulation and fibrinolysis. This study aimed to examine the relationship between biochemical markers associated with cognitive function and cognitive performance in men with prostate cancer (PC) following radical prostatectomy. Participants underwent a comprehensive evaluation, including clinical assessments (demographic information, medical history, PC progression, and complications such as erectile dysfunction [IIEF-5] and urinary incontinence [ICIQ-UI]), biochemical testing (testosterone, prostate-specific antigen, phosphorylated neurofilament heavy chain [pNF-H], brain-derived neurotrophic factor [BDNF], neuroserpin [NSP], and interleukin-6 [IL-6]), and neuropsychological assessment of cognitive functions. Statistical analysis revealed significant positive correlations between BDNF and NSP levels and performance on delayed memory tasks, specifically the number of correct responses. No other significant associations were found between protein biomarkers and cognitive test outcomes. These findings suggest that the relationship between biochemical markers and cognitive function is complex. However, BDNF and NSP may serve as potential biomarkers for delayed memory impairment in men post-prostatectomy.

Indexed as

Brain-Derived Neurotrophic FactorCognitionInterleukin-6Neurofilament ProteinsProstatic NeoplasmsSerpinsAgedBiomarkersBiomarkers, TumorHumansMaleMiddle AgedPlasminogen Activator Inhibitor 1ProstatectomyBDNF protein, humanBiomarkersBiomarkers, TumorBrain-Derived Neurotrophic FactorIL6 protein, humanInterleukin-6Neurofilament ProteinsPlasminogen Activator Inhibitor 1SERPINE1 protein, humanSerpinsBDNFbiochemical markerscognitive functionIl-6NSPpNF-Hprostate cancer

Identifiers

PMID41155494
PMCPMC12562499

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.