Evidence map›Paper›PMID 41155464›Full record

ReviewInternational journal of molecular sciences2025

Measuring the Invisible: Microbial Diagnostics for Periodontitis-A Narrative Review.

Michihiko Usui, Suzuka Miyagi, Rieko Yamanaka, Yuichiro Oka, Kaoru Kobayashi, Tsuyoshi Sato, Kotaro Sano, Satoru Onizuka, Maki Inoue, Wataru Fujii and 4 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michihiko UsuiDivision of Periodontology, Kyushu Dental University, Kitakyushu 803-8580, Japan.ORCID 0000-0002-5208-1848
Suzuka MiyagiDivision of Periodontology, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Rieko YamanakaDivision of Periodontology, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Yuichiro OkaDivision of Periodontology, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Kaoru KobayashiSchool of Oral Health Sciences, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Tsuyoshi SatoSchool of Oral Health Sciences, Kyushu Dental University, Kitakyushu 803-8580, Japan.ORCID 0000-0002-1109-196X
Kotaro SanoDivision of Periodontology, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Satoru OnizukaDivision of Periodontology, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Maki InoueDivision of Infections and Molecular Biology, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Wataru FujiiDivision of Dysphagia Rehabilitation, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Masanori IwasakiDivision of Preventive Dentistry, Department of Oral Health Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.ORCID 0000-0002-5739-2936
Wataru AriyoshiDivision of Infections and Molecular Biology, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Keisuke NakashimaFaculty of Dentistry, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Tatsuji NishiharaFaculty of Dentistry, Kyushu Dental University, Kitakyushu 803-8580, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is a biofilm-driven inflammatory disease in which conventional indices (probing depth, clinical attachment level, and radiographs) quantify tissue destruction without capturing the biology of infection. In this review, we synthesized microbiological diagnostics, from chairside tools to omics. We outline sampling strategies and emphasize the quantitative monitoring of bacterial load. Enzymatic assays (e.g., N-benzoyl-DL-arginine-2-naphthylamide hydrolysis assay test) measure functional activity at the point of care. Immunological methods include rapid immunochromatography for

Indexed as

Molecular Diagnostic TechniquesPeriodontitisHumansNucleic Acid Amplification TechniquesPorphyromonas gingivalisELISAenzymatic activity assayimmunochromatographymetagenomic analysismicroarraymicrobial diagnosticsperiodontitisreal-time PCR

Identifiers

PMID41155464
PMCPMC12562532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.