Evidence map›Paper›PMID 41155430›Full record

ArticleInternational journal of molecular sciences2025

Fungal Biotransformation of Chloroflavanones and Antimicrobial Activity of Parent Compounds and Derived Products.

Agnieszka Krawczyk-Łebek, Tomasz Janeczko, Barbara Żarowska, Edyta Kostrzewa-Susłow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Agnieszka Krawczyk-ŁebekDepartment of Food Chemistry and Biocatalysis, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.ORCID 0000-0002-9507-0196
Tomasz JaneczkoDepartment of Food Chemistry and Biocatalysis, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.ORCID 0000-0002-9757-6684
Barbara ŻarowskaDepartment of Biotechnology and Food Microbiology, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, 51-630 Wrocław, Poland.
Edyta Kostrzewa-SusłowDepartment of Food Chemistry and Biocatalysis, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.ORCID 0000-0002-9259-0161

Funding

National Science Center, Poland 2021/41/N/NZ9/01195
6 · The paper itself

Abstract

This study explores the synthesis of chlorine-substituted flavanones and their biotechnologically derived glycosides in order to evaluate how structural modifications influence both antimicrobial activity and pharmacokinetic properties, with attention to issues such as solubility and membrane transport. Four chloroflavanones (2'-, 3'-, 4'-, and 6-chloroflavanone) were synthesized and biotransformed using entomopathogenic fungi to obtain glycosylated derivatives. Antimicrobial activity was assessed against five microbial strains, while pharmacokinetic properties were predicted computationally. Results showed that 4'-chloroflavanone demonstrated the strongest antimicrobial activity, particularly against Gram-positive bacteria

Indexed as

Anti-Infective AgentsFlavanonesFungiBiotransformationCandida albicansEnterococcus faecalisEscherichia coliGlycosylationMicrobial Sensitivity TestsStaphylococcus aureusAnti-Infective AgentsFlavanonesantimicrobial activityBeauveria bassianabiotransformationsflavanones with a chlorine atomglycosylationIsaria fumosorosea

Identifiers

PMID41155430
PMCPMC12563750

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.