Evidence map›Paper›PMID 41155410›Full record

ArticleInternational journal of molecular sciences2025

Comparative Characterization of Tumor Microenvironments in Monophasic and Biphasic Synovial Sarcomas.

Anna Kosyreva, Enar Jumaniyazova, Alexandra Sentyabreva, Ekaterina Miroshnichenko, Dzhuliia Dzhalilova, Timur Fetisov, Anastasia Tararykova, Anastasiya Lokhonina, Timur Fatkhudinov

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Anna KosyrevaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.ORCID 0000-0002-6182-1799
Enar JumaniyazovaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
Alexandra SentyabrevaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.ORCID 0000-0001-5064-219X
Ekaterina MiroshnichenkoResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.ORCID 0000-0002-0020-958X
Dzhuliia DzhalilovaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.ORCID 0000-0002-1337-7160
Timur FetisovResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
Anastasia TararykovaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
Anastasiya LokhoninaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
Timur FatkhudinovResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.ORCID 0000-0002-6498-5764

Funding

Russian Science Foundation 23-65-00003
6 · The paper itself

Abstract

The impact of histological subtype on immunogenic properties of the tumor microenvironment in synovial sarcomas (SSs) remains understudied. This study aimed to conduct a comparative assessment of tumor microenvironments in monophasic and biphasic SSs. During the study, biomaterial from nine patients with SS was analyzed using IHC analysis, flow cytometry, and real-time PCR. All tumors were infiltrated with CD45+ leukocytes, including the diffusely scattered CD68+ macrophages. FAP+ cells were identified in 7/9 observations, including both monophasic and biphasic tumors. CD4+ T cells and CD20+ B cells were identified by IHC in biphasic SS. The flow cytometry assay revealed significantly higher counts of CD4+ and CD8+ lymphocytes in biphasic SS. IHC revealed E-cadherin expression specifically in the epithelial component of biphasic SS. Vimentin expression in the mesenchymal component of biphasic SS was stronger than in monophasic tumors. The reverse transcription real-time PCR assay revealed higher expression of tumor markers

Indexed as

Sarcoma, SynovialTumor MicroenvironmentAdultAgedBiomarkers, TumorFemaleHumansMacrophagesMaleMiddle AgedBiomarkers, Tumorbiphasic sarcomamonophasic sarcomasoft-tissue sarcomasynovial sarcomastumor-associated macrophagestumor microenvironments

Identifiers

PMID41155410
PMCPMC12563643

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