Evidence map›Paper›PMID 41155403›Full record

ArticleInternational journal of molecular sciences2025

Serum miR-34a as Indicator of Impaired Fibrinolytic Capacity in Pediatric Thrombosis Through Inadequate Regulation of the ACE/PAI-1 Axis.

Iphigenia Gintoni, Kleoniki Baldouni, Athina Dettoraki, Aikaterini Michalopoulou, Ioanna Papathanasiou, Aspasia Tsezou, Dimitrios Vlachakis, Helen Pergantou, George P Chrousos, Christos Yapijakis

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Iphigenia GintoniUnit of Orofacial Genetics, 1st Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, 115 27 Athens, Greece.ORCID 0009-0004-2561-9595
Kleoniki BaldouniUnit of Orofacial Genetics, 1st Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, 115 27 Athens, Greece.
Athina DettorakiHaemophilia Center for Children and Adolescents, Haemostasis and Thrombosis Unit, "Aghia Sophia" Children's Hospital, 115 27 Athens, Greece.ORCID 0000-0001-8232-3767
Aikaterini MichalopoulouHaemophilia Center for Children and Adolescents, Haemostasis and Thrombosis Unit, "Aghia Sophia" Children's Hospital, 115 27 Athens, Greece.
Ioanna PapathanasiouLaboratory of Cytogenetics and Molecular Genetics, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, 41500 Larissa, Greece.
Aspasia TsezouLaboratory of Cytogenetics and Molecular Genetics, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, 41500 Larissa, Greece.
Dimitrios VlachakisLaboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 11855 Athens, Greece.ORCID 0000-0003-1823-6102
Helen PergantouHaemophilia Center for Children and Adolescents, Haemostasis and Thrombosis Unit, "Aghia Sophia" Children's Hospital, 115 27 Athens, Greece.ORCID 0000-0002-1792-0597
George P ChrousosUniversity Research Institute of Maternal and Child Health and Precision Medicine, National Kapodistrian University of Athens, Choremion Laboratory, "Aghia Sophia" Children's Hospital, 115 27 Athens, Greece.ORCID 0000-0002-3098-5264
Christos YapijakisUnit of Orofacial Genetics, 1st Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, 115 27 Athens, Greece.ORCID 0000-0001-6695-186X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric thrombosis (PT) represents a rare condition that can manifest from neonatal life to adolescence, encompassing life-threatening complications. Its pathogenesis is attributed to immature hemostasis in conjunction with environmental and genetic factors, predominantly including those resulting in increased levels of plasminogen activator inhibitor 1 (PAI-1), the principal inhibitor of fibrinolysis, which is subject to upstream regulation by angiotensin-converting enzyme (ACE). Although the implication of microRNAs (miRNAs), epigenetic modulators of gene expression, has been demonstrated in adult thrombosis, evidence is lacking in the pediatric setting. Here, we investigated the involvement of two miRNA regulators of PAI-1 (

Indexed as

FibrinolysisMicroRNAsPeptidyl-Dipeptidase APlasminogen Activator Inhibitor 1ThrombosisAdolescentBiomarkersCase-Control StudiesChildChild, PreschoolFemaleGene Expression RegulationHumansInfantMaleACE protein, humanBiomarkersMicroRNAsMIRN34 microRNA, humanPeptidyl-Dipeptidase APlasminogen Activator Inhibitor 1SERPINE1 protein, humanACE I/D polymorphismadolescent thrombosiscoagulationepigeneticsfibrinolysismicroRNAmiR-145-5pmiR-34a-5pSERPINE1 4G/5G polymorphismstrokethrombophiliathrombosis in childhood

Identifiers

PMID41155403
PMCPMC12562870

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.