Evidence map›Paper›PMID 41155387›Full record

ArticleInternational journal of molecular sciences2025

Selective Paracrine Modulation of Stromal Cells: Wharton's Jelly MSC Secretome Enhances Adipose-Derived MSC Functionality While Maintaining Dermal Fibroblast Quiescence.

Tanya Stoyanova, Lora Topalova, Stanimir Kyurkchiev, Regina Komsa-Penkova, Svetla Todinova, George Altankov

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tanya StoyanovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0009-0001-6880-4174
Lora TopalovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0009-0003-7279-4348
Stanimir KyurkchievTissue Bank BulGen, 1330 Sofia, Bulgaria.
Regina Komsa-PenkovaCenter of Competence in Personalized Medicine, 3D and Telemedicine, Robotic Assisted and Minimally Invasive Surgery-"Leonardo da Vinci", 5800 Pleven, Bulgaria.ORCID 0000-0002-1349-9555
Svetla TodinovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0001-7108-051X
George AltankovCenter of Competence in Personalized Medicine, 3D and Telemedicine, Robotic Assisted and Minimally Invasive Surgery-"Leonardo da Vinci", 5800 Pleven, Bulgaria.

Funding

European Union NextGeneration EU, through the National Recovery and Resilience Plan of the Republic of Bulgaria project BG-RRP-2.004-0003PRIDST 2021-2027 and co-funded by the EU project BG16RFPR002-1.014-0002-С001 С001 "Centre of competence in personalized medicine, 3d and telemedicine, robotic assisted and minimally invasive surgery"
6 · The paper itself

Abstract

Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) secrete a rich array of paracrine factors including growth factors, cytokines, and extracellular vesicles that hold promises for regenerative medicine. This study evaluated the effects of WJ-MSC-derived secretome on adipose-derived mesenchymal stem cells (AD-MSCs) and human dermal fibroblasts (HDFs), focusing on their adhesion, spreading, proliferation, endogenous collagen secretion, and migration. Morphometric analysis revealed that the secretome enhanced cell adhesion and spreading on rat tail collagen (RTC) substrates after 24 h. AD-MSCs showed a ~30% increase in the cell spreading area (from 4007 μm

Indexed as

Adipose TissueFibroblastsMesenchymal Stem CellsParacrine CommunicationSecretomeWharton JellyAnimalsCell AdhesionCell MovementCell ProliferationCells, CulturedCollagenDermisHumansRatsCollagencollagen interaction secretionhuman adipose MSCsparacrine crosstalkprimary fibroblastssecretomeWharton’s jelly MSCswound healing

Identifiers

PMID41155387
PMCPMC12564346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.