Evidence map›Paper›PMID 41155343›Full record

ReviewInternational journal of molecular sciences2025

HPV-Independent Cervical Cancer-A New Challenge of Modern Oncology.

Ruxandra Maria Hurjui, Ion Andrei Hurjui, Tudor Andrei Buțureanu, Diana Popovici, Elena-Roxana Avădănei, Raluca Anca Balan

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ruxandra Maria HurjuiDepartment of Morpho-Functional Sciences I, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania.
Ion Andrei HurjuiDepartment of Medicine III, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.
Tudor Andrei BuțureanuDepartment Mother and Child Medicine, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.ORCID 0000-0002-6524-145X
Diana PopoviciDepartment Mother and Child Medicine, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.ORCID 0009-0007-8974-9761
Elena-Roxana AvădăneiDepartment of Morpho-Functional Sciences I, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania.
Raluca Anca BalanDepartment of Morpho-Functional Sciences I, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania.ORCID 0000-0003-2875-8991

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer is a major global health concern with serious implications for women's health. It is most often caused by persistent infection with high-risk human papillomavirus (HPV) types. However, about 5-11% of cervical carcinoma cases are HPV-independent, entities with their own unique set of histopathological, molecular, and clinical features. The histopathological forms of HPV-independent cervical cancer include gastric-type adenocarcinoma, clear-cell, mesonephric, and endometrioid carcinoma. Unlike HPV-associated cervical cancers, which require E6 and E7 oncogenes for their expression, HPV-independent tumors exhibit specific mutations such as

Indexed as

PapillomaviridaePapillomavirus InfectionsUterine Cervical NeoplasmsFemaleHumansMutationHPV-associated cervical adenocarcinomaHPV-associated cervical squamous carcinomaHPV-independent cervical adenocarcinomaHPV-independent cervical squamous carcinomamolecular classification of cervical cancer

Identifiers

PMID41155343
PMCPMC12563208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.