Evidence map›Paper›PMID 41155336›Full record

ArticleInternational journal of molecular sciences2025

Kdm7aa Orchestrates an Immunomodulatory Cardiomyocyte Program to Enable Zebrafish Heart Regeneration.

Weibin Lin, Yuan Shi, Jin Tian, Xinru Liu, Fubin Weng, Zekai Wu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Weibin LinKey Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou 350122, China.
Yuan ShiState Key Laboratory of Mariculture Breeding, College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.ORCID 0000-0002-8780-5420
Jin TianKey Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou 350122, China.
Xinru LiuKey Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou 350122, China.
Fubin WengKey Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou 350122, China.
Zekai WuKey Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou 350122, China.ORCID 0009-0001-5187-132X

Funding

Fujian Medical University High-level Talent Research Startup Funding Project XRCZX2023003Natural Science Foundation of Fujian Province 2024J01490Startup Fund for scientific research, Fujian Medical University 2022QH1005
6 · The paper itself

Abstract

Myocardial infarction triggers limited repair in adult mammals but robust regeneration in zebrafish. Epigenetic regulation and immune responses are recognized as critical for successful regeneration. However, the molecular links between these processes have not been fully elucidated. By performing single-cell RNA sequencing of zebrafish ventricular cardiomyocytes after injury, we identified a regeneration-induced immunomodulatory cluster that specifically expressed the histone demethylase gene

Indexed as

HeartHistone DemethylasesJumonji Domain-Containing Histone DemethylasesMyocytes, CardiacRegenerationZebrafishZebrafish ProteinsAnimalsEpigenesis, GeneticHumansImmunomodulationMiceHistone DemethylasesJumonji Domain-Containing Histone DemethylasesZebrafish Proteinschemokinesheart regenerationimmune responsekdm7aazebrafish

Identifiers

PMID41155336
PMCPMC12563937

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.