Evidence map›Paper›PMID 41155328›Full record

ArticleInternational journal of molecular sciences2025

Modular Virus-like Particles for Antigen Presentation: Comparing Genetic Fusion and Click-Chemistry for Purification.

Karsten Balbierer, Volker Jenzelewski, Fabian C Herrmann, Michael Piontek, Joachim Jose

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karsten BalbiererARTES Biotechnology GmbH, 40764 Langenfeld, Germany.ORCID 0009-0006-5085-6204
Volker JenzelewskiARTES Biotechnology GmbH, 40764 Langenfeld, Germany.
Fabian C HerrmannInstitute of Pharmaceutical Biology and Phytochemistry, University of Münster, 48149 Münster, Germany.
Michael PiontekARTES Biotechnology GmbH, 40764 Langenfeld, Germany.
Joachim JoseInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.ORCID 0000-0002-0666-2676

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent SARS-CoV-2 pandemic has highlighted the need for quickly adaptable technologies in vaccine manufacturing. This can be achieved through virus-like particles (VLPs) as presentation platforms for target antigens. In this study, we investigated the purification of VLPs of the Hepatitis B Core antigen (HBc) and the SplitCore (SplCo) technology. The outer surface protein C (OspC) of

Indexed as

Click ChemistryHepatitis B Core AntigensVaccines, Virus-Like ParticleBacterial Outer Membrane ProteinsCOVID-19Escherichia coliHumansRecombinant Fusion ProteinsSARS-CoV-2Bacterial Outer Membrane ProteinsHepatitis B Core AntigensRecombinant Fusion ProteinsVaccines, Virus-Like Particleantigen presentationclick-chemistryhepatitis B core antigen (HBc)virus-like particles (VLPs)

Identifiers

PMID41155328
PMCPMC12562343

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.