Evidence map›Paper›PMID 41155308›Full record

ArticleInternational journal of molecular sciences2025

Unraveling Lyophilization and Redispersion Effects on Miktoarm Polymer-Based Nanoformulations.

Samaneh Yousefi Adlsadabad, Gabriel Théberge-Julien, Fatima Fernanda Portillo Gutierrez, Ricardo Beltran Medina, Ximena Matias Mercado, Éric Rhéaume, Jean-Claude Tardif, Ashok Kakkar

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samaneh Yousefi AdlsadabadDepartment of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada.
Gabriel Théberge-JulienResearch Centre, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC H1T 1C8, Canada.
Fatima Fernanda Portillo GutierrezDepartment of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada.
Ricardo Beltran MedinaDepartment of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada.
Ximena Matias MercadoDepartment of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada.
Éric RhéaumeResearch Centre, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC H1T 1C8, Canada.ORCID 0000-0002-0554-0984
Jean-Claude TardifResearch Centre, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC H1T 1C8, Canada.ORCID 0000-0002-8200-8983
Ashok KakkarDepartment of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To enhance the scope of therapeutic interventions using star polymeric nanoparticles of desired concentrations, an understanding of the effect of converting aqueous formulations into stable redispersible dry powders by freeze drying on their physicochemical and biological properties is essential. We demonstrate that parameters such as the choice of the cryoprotectant, its molecular weight, and concentration play an important role during lyophilization and reconstitution processes. We hypothesized that utilizing cryoprotectants akin to shell-forming polymers may be ideal in protection against aggregation and keeping the nanostructures intact during lyophilization and reconstitution, as well as retaining the overall biological efficacy of their cargo. Through an evaluation of miktoarm polymer-based nanoparticles, we demonstrate that PEG

Indexed as

NanoparticlesPolymersAnimalsCryoprotective AgentsDrug CompoundingDrug LiberationFreeze DryingHumansPolyethylene GlycolsCryoprotective AgentsPolyethylene GlycolsPolymerscurcumin-loaded nanoformulationsdrug deliverylyophilization/redispersionnanoformulationspolymeric nanoparticles

Identifiers

PMID41155308
PMCPMC12563623

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.