Evidence map›Paper›PMID 41155286›Full record

Observational studyInternational journal of molecular sciences2025

Role of the Inflammasome Pathway According to the Expression of Proteins and Genetic Polymorphisms in COVID-19 Patients.

Thiago Rodrigues Dos Santos, Lucas Baena Carstens, Leonardo Vinícius Barbosa, Mariana Collete, Natan de Araujo, Caroline Busatta Vaz de Paula, Marina Luise Viola Azevedo, Ana Clara de Almeida, Seigo Nagashima, Lucia de Noronha and 1 more

Abstract readObservational Study
In one paragraph

Observational study in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thiago Rodrigues Dos SantosPostgraduate Program of Biotechnology Applied to Child and Adolescent, Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, Av. Silva Jardim, 1632, Curitiba 80250-200, PR, Brazil.ORCID 0009-0009-2970-710X
Lucas Baena CarstensPostgraduate Program of Health Sciences, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná-PUCPR, Rua Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil.ORCID 0000-0003-3391-9913
Leonardo Vinícius BarbosaPostgraduate Program of Biotechnology Applied to Child and Adolescent, Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, Av. Silva Jardim, 1632, Curitiba 80250-200, PR, Brazil.
Mariana ColletePostgraduate Program of Health Sciences, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná-PUCPR, Rua Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil.ORCID 0000-0002-2372-3397
Natan de AraujoPostgraduate Program of Health Sciences, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná-PUCPR, Rua Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil.ORCID 0009-0004-4163-7355
Caroline Busatta Vaz de PaulaLaboratory of Experimental Pathology, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná-PUCPR, Rua Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil.ORCID 0000-0002-8434-8471
Marina Luise Viola AzevedoLaboratory of Experimental Pathology, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná-PUCPR, Rua Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil.
Ana Clara de AlmeidaLaboratory of Experimental Pathology, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná-PUCPR, Rua Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil.
Seigo NagashimaLaboratory of Experimental Pathology, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná-PUCPR, Rua Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil.
Lucia de NoronhaPostgraduate Program of Health Sciences, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná-PUCPR, Rua Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil.ORCID 0000-0003-0310-7164
Cleber Machado-SouzaPostgraduate Program of Biotechnology Applied to Child and Adolescent, Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, Av. Silva Jardim, 1632, Curitiba 80250-200, PR, Brazil.ORCID 0000-0003-0565-3492

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 severity is frequently linked to exacerbated inflammation, with the inflammasome pathway playing a key role in activating inflammatory interleukins. This observational

Indexed as

COVID-19InflammasomesAgedAngiotensin-Converting Enzyme 2FemaleHumansInterleukin-18LungMaleMiddle AgedNADPH Oxidase 4NF-kappa B p50 SubunitNLR Family, Pyrin Domain-Containing 3 ProteinPolymorphism, Single NucleotideSARS-CoV-2Toll-Like Receptor 4Angiotensin-Converting Enzyme 2InflammasomesInterleukin-18NADPH Oxidase 4NF-kappa B p50 SubunitNFKB1 protein, humanNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNOX4 protein, humanTLR4 protein, humanToll-Like Receptor 4COVID-19 wavesinflammasomepiroptosepolymorphismsSARS-CoV-2

Identifiers

PMID41155286
PMCPMC12564305

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.