Evidence map›Paper›PMID 41155279›Full record

ArticleInternational journal of molecular sciences2025

Optimizing Positive End-Expiratory Pressure in Asymmetric Acute Lung Injury in a Porcine Model: The Role of Transpulmonary Pressure.

Claudine H Mutschler, Benjamin Seybold, Stefan Aschauer, Nils Englert, Cleo-Aron Weis, Tanja Poth, Defne Cetiner, Mark O Wielpütz, Dorothea Kehr, Markus A Weigand and 2 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Claudine H MutschlerMedical Faculty, Department of Anesthesiology, University Heidelberg, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Benjamin SeyboldMedical Faculty, Department of Anesthesiology, University Heidelberg, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0009-0003-6110-2713
Stefan AschauerMedical Faculty, Department of Anesthesiology, University Heidelberg, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Nils EnglertGerman Center for Lung Research (DZL), Translational Lung Research Center Heidelberg (TLRC), 69120 Heidelberg, Germany.
Cleo-Aron WeisMedical Faculty, Institute of Pathology, University Heidelberg, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Tanja PothCenter for Model System and Comparative Pathology (CMCP), Heidelberg University Hospital, 69120 Heidelberg, Germany.
Defne CetinerGerman Center for Lung Research (DZL), Translational Lung Research Center Heidelberg (TLRC), 69120 Heidelberg, Germany.
Mark O WielpützGerman Center for Lung Research (DZL), Translational Lung Research Center Heidelberg (TLRC), 69120 Heidelberg, Germany.
Dorothea KehrMedical Faculty, Department of Molecular and Translational Cardiology, University Heidelberg, 69117 Heidelberg, Germany.
Markus A WeigandMedical Faculty, Department of Anesthesiology, University Heidelberg, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Armin KalenkaMedical Faculty, Department of Anesthesiology, University Heidelberg, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Mascha O Fiedler-KalenkaMedical Faculty, Department of Anesthesiology, University Heidelberg, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0002-0127-2783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute hypoxemic respiratory failure is a critical challenge in intensive care. A substantial proportion of patients present with asymmetric acute lung injury (ALI), complicating management due to heterogeneous lung involvement. While lung-protective mechanical ventilation represents the standard of care, the optimal approach to positive end-expiratory pressure (PEEP) titration remains unclear. This study investigated the effects of transpulmonary pressure (TPP)-guided PEEP titration vs. a fixed PEEP strategy in a porcine model of unilateral ALI. A total of 14 pigs underwent ALI induction via unilateral surfactant depletion and were randomized to receive either a fixed PEEP of 5 cmH

Indexed as

Acute Lung InjuryPositive-Pressure RespirationAnimalsBiomarkersCytokinesDisease Models, AnimalFemaleLungRespiratory MechanicsSwineTidal VolumeTomography, X-Ray ComputedBiomarkersCytokinesacute respiratory distress syndromeasymmetric acute lung injurymechanical ventilationporcine modeltranspulmonary pressure

Identifiers

PMID41155279
PMCPMC12563547

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.