Evidence map›Paper›PMID 41155270›Full record

ArticleInternational journal of molecular sciences2025

Estradiol Triggers Cerebellar MLI-PC LTP via ERβ/Protein Kinase C Signaling Cascades in Mice In Vivo.

Zhao-Yi Zhang, Li Chen, Ming-Ze Sun, Chao-Yue Chen, Chun-Yan Wang, Yuki Todo, Zheng Tang, Yan-Cong Lv, Qin-Yong Zou, Chun-Ping Chu and 2 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [EstradiolZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhao-Yi ZhangDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
Li ChenDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
Ming-Ze SunDepartment of Neural Circuit, Institute of Brain Science, Jilin Medical University, Jilin 132013, China.
Chao-Yue ChenDepartment of Neural Circuit, Institute of Brain Science, Jilin Medical University, Jilin 132013, China.
Chun-Yan WangDepartment of Neural Circuit, Institute of Brain Science, Jilin Medical University, Jilin 132013, China.
Yuki TodoFaculty of Electrical, Information and Communication Engineering, Kanazawa University, Kanazawa 920-1192, Ishikawa, Japan.ORCID 0000-0001-7379-1374
Zheng TangSchool of Computer Engineering and Science, Shanghai University, Shanghai 200444, China.
Yan-Cong LvDepartment of Neural Circuit, Institute of Brain Science, Jilin Medical University, Jilin 132013, China.
Qin-Yong ZouDepartment of Neural Circuit, Institute of Brain Science, Jilin Medical University, Jilin 132013, China.
Chun-Ping ChuDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.ORCID 0009-0006-6921-5028
Yin-Hua XuDepartment of Neural Circuit, Institute of Brain Science, Jilin Medical University, Jilin 132013, China.ORCID 0009-0005-2152-3024
De-Lai QiuDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.ORCID 0000-0001-8825-4707

Funding

the Major Projects of the Ministry of Science and Technology of China 2021ZD0202300the National Natural Science Foundations of China 32070986the National Natural Science Foundations of China 32171005
6 · The paper itself

Abstract

17β-estradiol (E2) enhances the cerebellar molecular layer interneurons (MLIs)-Purkinje cells (PCs) synaptic transmission via activation of the Erβ in vivo in mice. Whether E2 regulates cerebellar MLI-PC synaptic plasticity is unknown. To investigate the mechanism of E2, we evaluated the modulation of facial stimulation-evoked MLI-PC long-term plasticity in mice. Cell-attached recordings from PCs of Crus II were performed using an Axopatch-700B patch-clamp amplifier. The MLI-PC synaptic transmission was evoked by facial stimulation. Immunohistochemistry was used to detect the expression of ERβ. Under control conditions, 1 Hz facial stimuli induced long-term depression (LTD) at MLI-PC synapses, characterized by a sustained reduction in P1 amplitude and a simple spike (SS) pause. The facial stimulus-induced MLI-PC LTD was completely prevented by E2, but this effect was reversed by a selective ERα/ERβ antagonist, ICI182780. Blockade of cannabinoid receptor 1 (CB1R) eliminated the MLI-PC LTD under control conditions, but revealed an E2-triggered long-term potentiation (LTP). The E2-triggered MLI-PC LTP persisted in the presence of an ERα antagonist but was absent in the presence of an ERβ antagonist PHTPP. The E2-triggered MLI-PC LTP remained unaffected by protein kinase A inhibition but was abolished by inhibition of protein kinase C (PKC) and intracellular Ca

Indexed as

CerebellumEstradiolEstrogen Receptor betaLong-Term PotentiationProtein Kinase CPurkinje CellsSignal TransductionAnimalsFemaleLong-Term Synaptic DepressionMaleMiceMice, Inbred C57BLSynaptic TransmissionEstradiolEstrogen Receptor betaProtein Kinase Ccerebellar molecular layer interneuron–Purkinje cell synaptic transmissionestrogen receptorsin vivo cell-attached recordingprotein kinase C (PKC)sensory stimulation

Identifiers

PMID41155270
PMCPMC12562853

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.