Evidence map›Paper›PMID 41155235›Full record

ArticleInternational journal of molecular sciences2025

The Esc(1-21)-1c Antimicrobial Peptide Inhibits a Specific Transcriptional Activator of the MexAB-OprM Efflux Pump in

Carolina Canè, Bruno Casciaro, Carlo Vetrano, Lidia Tammaro, Chiara Platella, Domenica Musumeci, Maria Luisa Mangoni, Angela Duilio, Angela Di Somma

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carolina CanèDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0003-4545-0737
Bruno CasciaroLaboratory Affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-1295-1084
Carlo VetranoLaboratory Affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0009-0003-5181-7301
Lidia TammaroCEINGE Biotecnologie Avanzate, 80145 Naples, Italy.ORCID 0009-0006-4148-2968
Chiara PlatellaDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.ORCID 0000-0002-6997-1767
Domenica MusumeciDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.ORCID 0000-0001-7624-1933
Maria Luisa MangoniLaboratory Affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-5991-5868
Angela DuilioDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.
Angela Di SommaDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.ORCID 0000-0003-4916-7875

Funding

European Union's Next Generation EU-Italian Ministry of University and Research (MUR) PRIN-PNRR P2022BWS27) European Union's Next Generation EU-MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases PE00000007, INF-ACT, node 3the European Union - NextGenerationEU, National Recovery and Resilience Plan (PNRR) CN00000041 "National Center for Gene Therapy and Drugs based on RNA Technology
6 · The paper itself

Abstract

The emergence of multidrug-resistant

Indexed as

Antimicrobial PeptidesBacterial Outer Membrane ProteinsMembrane Transport ProteinsPseudomonas aeruginosaTranscriptional ActivationAnti-Bacterial AgentsGene Expression Regulation, BacterialMolecular Docking SimulationPromoter Regions, GeneticProtein BindingAnti-Bacterial AgentsAntimicrobial PeptidesBacterial Outer Membrane ProteinsMembrane Transport ProteinsMexA protein, Pseudomonas aeruginosaMexB protein, Pseudomonas aeruginosaOprM protein, Pseudomonas aeruginosaEsc (1-21)-1cMexAB-OprM efflux pumpQ9I5H3 regulatory protein

Identifiers

PMID41155235
PMCPMC12563431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.