Evidence map›Paper›PMID 41155224›Full record

ArticleInternational journal of molecular sciences2025

Gout Risk Allele Regulating

Valentin Nica, Orsolya Gaal, Medeea Badii, Georgiana Cabău, Andreea-Manuela Mirea, Ioana Hotea, Cristina Pamfil, Simona Rednic, Radu A Popp, Mihai G Netea and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Valentin NicaDepartment of Translational Immunology, Medfuture Institute for Biomedical Research, "Iuliu Hațieganu" University of Medicine and Pharmacy, Str. Pasteur Nr. 6, 400349 Cluj-Napoca, Romania.
Orsolya GaalDepartment of Translational Immunology, Medfuture Institute for Biomedical Research, "Iuliu Hațieganu" University of Medicine and Pharmacy, Str. Pasteur Nr. 6, 400349 Cluj-Napoca, Romania.
Medeea BadiiDepartment of Translational Immunology, Medfuture Institute for Biomedical Research, "Iuliu Hațieganu" University of Medicine and Pharmacy, Str. Pasteur Nr. 6, 400349 Cluj-Napoca, Romania.
Georgiana CabăuDepartment of Translational Immunology, Medfuture Institute for Biomedical Research, "Iuliu Hațieganu" University of Medicine and Pharmacy, Str. Pasteur Nr. 6, 400349 Cluj-Napoca, Romania.
Andreea-Manuela MireaDepartment of Medical Genetics, "Iuliu Hațieganu" University of Medicine and Pharmacy, Str. Pasteur Nr. 6, 400349 Cluj-Napoca, Romania.ORCID 0000-0002-9297-9871
Ioana HoteaDepartment of Rheumatology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Str. Clinicilor 2-4, 400006 Cluj-Napoca, Romania.
Cristina PamfilDepartment of Rheumatology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Str. Clinicilor 2-4, 400006 Cluj-Napoca, Romania.
Simona RednicDepartment of Rheumatology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Str. Clinicilor 2-4, 400006 Cluj-Napoca, Romania.
Radu A PoppDepartment of Medical Genetics, "Iuliu Hațieganu" University of Medicine and Pharmacy, Str. Pasteur Nr. 6, 400349 Cluj-Napoca, Romania.
Mihai G NeteaDepartment of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands.
Tania O CrișanDepartment of Translational Immunology, Medfuture Institute for Biomedical Research, "Iuliu Hațieganu" University of Medicine and Pharmacy, Str. Pasteur Nr. 6, 400349 Cluj-Napoca, Romania.
Leo A B JoostenDepartment of Translational Immunology, Medfuture Institute for Biomedical Research, "Iuliu Hațieganu" University of Medicine and Pharmacy, Str. Pasteur Nr. 6, 400349 Cluj-Napoca, Romania.ORCID 0000-0001-6166-9830
Hint Consortium

Funding

Competitiveness Operational Programme grant of the Romanian Ministry of European Funds P_37_762, MySMIS 103587PCD grant for doctoral research of the University of Medicine and Pharmacy "Iuliu Hațieganu" 2461/51Romania's National Recovery and Resilience Plan grant of the Romanian Ministry of Investments and European Projects PNRR-III-C9-2022-I8, CF 85/15.11.2022
6 · The paper itself

Abstract

Interferon Regulatory Factor 5 plays an important role in the regulation of innate immune responses by amplifying the Nuclear Factor κB response, which is critical in gout inflammation. Furthermore, the rs4728141 polymorphism C allele was associated with both increased

Indexed as

GoutInterferon Regulatory FactorsInterleukin-1betaPalmitatesUric AcidAdultAgedAllelesFemaleGene Expression RegulationGenetic Predisposition to DiseaseHumansLeukocytes, MononuclearMaleMiddle AgedPolymorphism, Single NucleotideInterferon Regulatory FactorsInterleukin-1betaIRF5 protein, humanPalmitatesUric Acidgoutinflammationinterferon regulatory factor 5interleukin-1

Identifiers

PMID41155224
PMCPMC12563284

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.