Evidence map›Paper›PMID 41155216›Full record

ArticleInternational journal of molecular sciences2025

Multiomics Investigation of Exhausted T Cells in Glioblastoma Tumor Microenvironment:

Ruihao Qin, Menglei Hua, Yaru Wang, Qi Zhang, Yong Cao, Yanyan Dai, Chenjing Ma, Xiaohan Zheng, Kaiyuan Ge, Huimin Zhang and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ruihao QinDepartment of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.ORCID 0009-0007-5352-5133
Menglei HuaDepartment of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.
Yaru WangDepartment of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.
Qi ZhangDepartment of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.
Yong CaoDepartment of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.
Yanyan DaiDepartment of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.
Chenjing MaDepartment of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.
Xiaohan ZhengDepartment of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.
Kaiyuan GeDepartment of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.
Huimin ZhangDepartment of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.
Shi LiLaboratory for the Study of Metastatic Microenvironments, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Yan LiuDepartment of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.ORCID 0000-0003-1437-7231
Lei CaoDepartment of Biostatistics, School of Public Health, Harbin Medical University, Harbin 150086, China.
Liuying WangSchool of Health Management, Harbin Medical University, Harbin 150086, China.

Funding

National Natural Science Foundation of China 82173629National Natural Science Foundation of China 82273734National Natural Science Foundation of China 82304250
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is a common malignancy with poor prognosis, and exhausted T (TEX) cells, a subset of T cells characterized by progressive loss of effector functions, play a critical role in its progression. This study aimed to investigate the impact of TEX-related genes on immune function, prognosis, and drug sensitivity in GBM through multiomics analysis. Initially, we identified a novel set of TEX-related genes specific to GBM and screened hub genes (

Indexed as

Brain NeoplasmsChemokine CCL5GlioblastomaT-LymphocytesTumor MicroenvironmentBiomarkers, TumorGene Expression Regulation, NeoplasticHumansMultiomicsPrognosisBiomarkers, TumorCCL5 protein, humanChemokine CCL5CCL5drug sensitivityexhausted T cellGBMmultiomics

Identifiers

PMID41155216
PMCPMC12563952

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.