Evidence map›Paper›PMID 41155132›Full record

ArticleInternational journal of molecular sciences2025

Role of Repeat Tract Structure and the rs7158733 SNP in Spinocerebellar Ataxia 3.

Suran Nethisinghe, Hector Garcia-Moreno, Jude Alwan, Robyn Labrum, Paola Giunti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Suran NethisingheAtaxia Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.ORCID 0000-0002-4272-9292
Hector Garcia-MorenoAtaxia Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.ORCID 0000-0002-0697-3271
Jude AlwanAtaxia Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Robyn LabrumNeurogenetics Service, Rare and Inherited Disease Laboratory, London North Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3BH, UK.
Paola GiuntiAtaxia Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.ORCID 0000-0003-3508-4788

Funding

Medical Research Council MR/N028767/1 ESMI
6 · The paper itself

Abstract

Spinocerebellar ataxia 3 (SCA3) is a neurodegenerative condition caused by an expansion of a polyglutamine tract within the

Indexed as

Ataxin-3Machado-Joseph DiseasePolymorphism, Single NucleotideAdultAgedAllelesFemaleGenotypeHumansMaleMiddle AgedRepressor ProteinsTrinucleotide Repeat ExpansionAtaxin-3ATXN3 protein, humanRepressor ProteinsataxiaCAG repeatPolyQSCA3single-nucleotide polymorphismSpinocerebellar ataxia 3

Identifiers

PMID41155132
PMCPMC12563690

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.