ArticleBioengineering (Basel, Switzerland)2025
Joint Kinematics and Gait Pattern in Multiple Sclerosis: A 3D Analysis Comparative Approach.
Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This cross-sectional study analyzed the lower limb (LL) behavior in terms of gait asymmetry and joints' kinematic parameters, comparing people with multiple sclerosis (pwMS) and unaffected individuals.
methodsData from 15 patients, EDSS ≤ 4.5, and 15 healthy control volunteers were gathered. The VICON Motion Capture System (14 infrared cameras), NEXUS software, Plug-in-Gait skeleton model and reflective markers were used to collect data for each subject during five gait cycles on a plane surface. Biomechanical analysis included evaluation of LL joints' range of motion (ROM) bilaterally, as well as movement symmetry.
resultsComparative biomechanical analysis revealed a hierarchy of vulnerability between the groups: the ankle is the most affected joint in pwMS (
conclusionsMS does not affect the joints structurally; rather, it eliminates the ability to differentiate the fine-tuning control between them. The absence of significant left-right joint asymmetry differences during complete gait cycle indicates dysfunction in the global motor control.
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