Evidence map›Paper›PMID 41155007›Full record

ArticleBioengineering (Basel, Switzerland)2025

Evaluation of UNeXt for Automatic Bone Surface Segmentation on Ultrasound Imaging in Image-Guided Pediatric Surgery.

Jasper M van der Zee, Aimon M Rahman, Kevin Klein Gunnewiek, Marijn A J Hiep, Matthijs Fitski, Ilker Hacihaliloglu, Ahmed Z Alsinan, Vishal M Patel, Annemieke S Littooij, Alida F W van der Steeg

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Performance of a tracked ultrasound navigation setup for pediatric tumor surgery: a phantom study.International journal of computer assisted radiology and surgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jasper M van der ZeeDepartment of Pediatric Surgery, Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.ORCID 0000-0001-9144-8852
Aimon M RahmanDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Kevin Klein GunnewiekDepartment of Pediatric Surgery, Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.ORCID 0009-0006-5476-6820
Marijn A J HiepDepartment of Surgical Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.ORCID 0000-0002-7362-8515
Matthijs FitskiDepartment of Pediatric Surgery, Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.ORCID 0000-0003-0515-7691
Ilker HacihalilogluDepartment of Radiology, Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Ahmed Z AlsinanDepartment of Electrical and Computer Engineering, Rutgers University, Piscataway, NJ 08854, USA.
Vishal M PatelDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Annemieke S LittooijDepartment of Pediatric Surgery, Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.
Alida F W van der SteegDepartment of Pediatric Surgery, Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.ORCID 0000-0003-0168-7513

Funding

KWF Dutch Cancer Society - Alphe d'Huzes 16145
6 · The paper itself

Abstract

Automatic bone surface segmentation represents an advanced alternative for conventional patient registration methods in surgical navigation technologies. In pediatrics, such technologies require tailored approaches to ensure optimal performance-specifically in patients under the age of ten, whose immature bones have less distinct bone characteristics. In this study, we developed a segmentation model tailored for pediatric patients. We captured 4309 ultrasound images from the bones in the extremities, pelvis and thorax of 16 pediatric patients. The dataset was manually annotated by a technical physician and sample-wise validated by a pediatric radiologist. A UNeXt deep learning model was trained for automatic segmentation. The segmentation performance was evaluated using the mean centerline Dice score and the mean surface distance. A mean centerline Dice score of 0.85 (SD: 0.13) and a mean surface distance of 0.78 mm (SD: 1.15 mm) were achieved. No important differences in performance were observed for patients younger than the age of ten compared to older patients. Our results demonstrate that the segmentation model detects the bone surface with sufficient accuracy, enabling precise and effective patient registration. The model performs sufficiently across different pediatric age groups, making it a viable tool for integration into ultrasound-based patient registration in image-guided pediatric surgery.

Indexed as

image-guided surgerypatient registrationpediatric oncology surgerytracked ultrasound

Identifiers

PMID41155007
PMCPMC12561024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.