Evidence map›Paper›PMID 41154661›Full record

ReviewBiomolecules2025

A Neural-Glial Model of the ApoE-SORT1-FABP7 Axis Tied to Sleep Disruption and Alzheimer's Disease Pathophysiology.

Carlos C Flores, Yool Lee, Christopher J Davis, Patrick Solverson, Jason R Gerstner

Abstract readReview
In one paragraph

Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carlos C FloresTranslational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.ORCID 0000-0003-3771-0906
Yool LeeTranslational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.ORCID 0000-0003-0498-3342
Christopher J DavisTranslational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.ORCID 0000-0002-9613-928X
Patrick SolversonNutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.ORCID 0000-0003-0858-9844
Jason R GerstnerTranslational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.ORCID 0000-0003-3113-6974

Funding

Characterizing evolutionarily conserved mechanisms underlying sleep, clocks, and memoryR35GM133440 · NIGMS · WASHINGTON STATE UNIVERSITY · PI GERSTNER, JASON ROBERT · 2019 to 2023
$2.3M
Reciprocal Interactions Linking Cognitive Performance, Aβ aggregation, and Transcriptional Processing with Sleep Disruption in an Alzheimer's Disease ModelR21AG096297 · NIA · WASHINGTON STATE UNIVERSITY · PI DAVIS, CHRISTOPHER JOHN, GERSTNER, JASON ROBERT · 2025 to 2025
$421k
NIA NIH HHS R21 AG096297NIGMS NIH HHS R35 GM133440NIH HHS 1R21AG096297-01NIH HHS 1R35GM133440-05
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disorder where age, genetic factors and sleep disturbance significantly influence disease risk. Recent genome-wide association studies identified a C/T missense variant (rs141749679) in the sortilin (

Indexed as

Adaptor Proteins, Vesicular TransportAlzheimer DiseaseApolipoproteins EFatty Acid-Binding Protein 7NeurogliaSleep Wake DisordersAnimalsHumansNeuronsSignal TransductionSortilinTumor Suppressor ProteinsAdaptor Proteins, Vesicular TransportApolipoproteins EFABP7 protein, humanFatty Acid-Binding Protein 7SortilinTumor Suppressor Proteinsastrocytecircadianexcitabilitymetabolismneurodegeneration

Identifiers

PMID41154661
PMCPMC12564076

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.