ArticleBiomolecules2025
The ExPAND Study: A Prospective Association Study into Endometriosis-Associated Pain, Neurosteroid Synthesis, and TRPM3.
Eleonora Persoons, Celine Bafort, Pilar Van Mechelen, Martina Ciprietti, Katrien Luyten, Melissa Benoit, Arne Vanhie, Thomas Voets, Carla Tomassetti, Joris Vriens
Abstract read
In one paragraphArticle in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Eleonora PersoonsImplantation, Placentation, Pregnancy and Endometriosis (POPPYe) Research Group, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
Celine BafortImplantation, Placentation, Pregnancy and Endometriosis (POPPYe) Research Group, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-0476-1304 Pilar Van MechelenImplantation, Placentation, Pregnancy and Endometriosis (POPPYe) Research Group, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.ORCID 0009-0003-7212-4969 Martina CipriettiImplantation, Placentation, Pregnancy and Endometriosis (POPPYe) Research Group, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-7209-7604 Katrien LuytenImplantation, Placentation, Pregnancy and Endometriosis (POPPYe) Research Group, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
Melissa BenoitLaboratory of Ion Channel Research (LICR), VIB-KU Leuven Center for Brain & Disease Research, Belgium & Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
Arne VanhieImplantation, Placentation, Pregnancy and Endometriosis (POPPYe) Research Group, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
Thomas VoetsLaboratory of Ion Channel Research (LICR), VIB-KU Leuven Center for Brain & Disease Research, Belgium & Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-5526-5821 Carla TomassettiImplantation, Placentation, Pregnancy and Endometriosis (POPPYe) Research Group, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
Joris VriensImplantation, Placentation, Pregnancy and Endometriosis (POPPYe) Research Group, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-2502-0409 Funding
Research Council of the KU Leuven C14/24/152Research Foundation - Flanders G.084515NResearch Foundation - Flanders G.0B1819NResearch Foundation - Flanders G.1223425N
6 · The paper itselfAbstract
Endometriosis-associated pain has debilitating effects on the quality of life of patients. Despite its high prevalence in reproductive-aged women, the pathophysiology is still unknown, impeding the development of targeted treatment approaches. The prospective ExPAND study proposes the neurosteroids pregnenolone sulphate (PS) and dehydroepiandrosterone sulphate (DHEAS) as potential contributors to endometriosis-associated pain, due to their agonistic action at the pain-related ion channel TRPM3. To this end, endometrium, deep endometriosis lesions, and peritoneal fluid were prospectively collected in four demarcated patient groups, which were characterised based on their pain symptoms, as scored via the WERF-EPHect questionnaire, i.e., (1) control (
Indexed as
EndometriosisNeurosteroidsPainPelvic PainPregnenoloneTRPM Cation ChannelsAdultDehydroepiandrosterone SulfateDysmenorrheaEndometriumFemaleHumansProspective StudiesDehydroepiandrosterone SulfateNeurosteroidsPregnenolonepregnenolone sulfateTRPM3 protein, humanTRPM Cation ChannelsDHEASendometriosispainPSsteroidogenesisTRPM3
Identifiers
PMID41154581
PMCPMC12563993
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