ArticleAntioxidants (Basel, Switzerland)2025
Oxidative Stress-Related Biomarkers in Inflammatory Bowel Disease: Dual Tools for Remission Assessment and Prediction of Treatment Outcome.
Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Anti-inflammatory and antioxidative stress effects ofAnnals of medicine and surgery (2012) · 2026Article
- Modulation of Oxidative Stress and Nuclear Factor-κB- Associated Inflammatory Signaling by Rabeprazole in Acetic Acid-Induced Colonic InjuryThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- 8-Epi-Prostaglandin F2α as a Redox Biomarker in Inflammatory Bowel Disease.Biomedicines · 2026Article
- Nrf2 as a Molecular Guardian of Redox Balance and Barrier Integrity in IBD.Antioxidants (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Oxidative stress is increasingly recognized as a significant contributor to the pathogenesis of inflammatory bowel disease (IBD). However, the clinical utility of oxidative stress-related biomarkers for assessing and predicting disease activity remains unclear. This prospective observational study aimed to evaluate the diagnostic and predictive performance of oxidative stress-related biomarkers in distinguishing between active IBD and remission across clinical, biochemical, and endoscopic criteria. A total of 76 patients with IBD were followed across three visits: baseline (biological treatment initiation), post-induction (6-12 weeks), and final follow-up (24-36 weeks). Associations with clinical, biochemical, and endoscopic remission status at the final follow-up were evaluated using correlation matrices, receiver operating characteristic curve analysis, principal component analysis, and logistic regression. Ceruloplasmin, plasma free thiols, gamma-glutamyl transferase, and albumin showed significant diagnostic values for distinguishing active disease from remission, using C-reactive protein (CRP)-based criteria. Serum uric acid, advanced oxidation protein products, gamma-glutamyl transferase, total antioxidant capacity, and ceruloplasmin predicted clinical or CRP-based remission when measured at baseline or post-induction, with predictive value varying by biomarker and the time point. Overall, our findings reinforce the role of oxidative stress in the pathogenesis of IBD and highlight the potential of oxidative stress-related biomarkers to be used as tools for monitoring disease activity and predicting IBD treatment outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.