Internal Exposure to BTEX in Tropical Children: Does Exposure Speed Up Pubertal Development?

Yao Lu, Qin Zhou, Dan Wang, Yu-Ling Luan, Ying Guo

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yao LuGuangdong Key Laboratory of Environmental Pollution and Health, School of Environment and Climate, Jinan University, Guangzhou 511443, China.

Qin ZhouGuangdong Key Laboratory of Environmental Pollution and Health, School of Environment and Climate, Jinan University, Guangzhou 511443, China.

Dan WangHainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya 572000, China.

Yu-Ling LuanGuangdong Key Laboratory of Environmental Pollution and Health, School of Environment and Climate, Jinan University, Guangzhou 511443, China.

Ying GuoGuangdong Key Laboratory of Environmental Pollution and Health, School of Environment and Climate, Jinan University, Guangzhou 511443, China.

Funding

Joint Program on Health Science & Technology Innovation of Hainan Province, China SQ2023WSJK0572National Key Research and Development Program of China 2024YFC3908701National Natural Science Foundation of China 22176071Natural Science Foundation of Guangdong Province, China 2023A1515011879

6 · The paper itself

Abstract

Benzene, toluene, ethylbenzene, and xylene (BTEX) are a common class of volatile organic compounds linked to adverse health outcomes. Although BTEX have been shown to have endocrine disrupting properties, their potential impacts on pubertal development in children remain unclear. In this study, for the first time, we investigated the possible association of BTEX exposure with precocious puberty (PP) and early puberty (EP) in children. We conducted a case-control study that included 246 children diagnosed with PP or EP and a controls category matched for sex and age. Urinary concentrations of seven BTEX metabolites and the oxidative DNA damage biomarker 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured by high-performance liquid chromatography-tandem mass spectrometry. Compared with the control groups, urinary catechol (1,2-DB) levels were significantly higher in both PP (median: 85.3 vs. 42.4 μg/g creatinine) and EP children (median: 62.0 vs. 48.1 μg/g creatinine). Binary logistic regression models showed that 1,2-DB was positively associated with EP (OR = 1.36, 95% CI: 1.10, 1.69), while

Indexed as

BTEXearly pubertyinternal exposureoxidative DNA damageprecocious puberty

Identifiers

PMID41154473

DOI10.3390/antiox14101164

PMCPMC12561042

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.