Evidence map›Paper›PMID 41154455›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Plasma Glycated and Oxidized Amino Acid-Based Screening Test for Clinical Early-Stage Osteoarthritis.

Aisha Nasser J M Al-Saei, Usman Ahmed, Edward J Dickenson, Kashif Rajpoot, Mingzhan Xue, Essam M Abdelalim, Abdelilah Arredouani, Omar M E Albagha, Damian R Griffin, Paul J Thornalley and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aisha Nasser J M Al-SaeiDepartment of Basic Medical Science, College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0001-9380-3221
Usman AhmedWorcestershire Acute Hospitals NHS Trust, Charles Hastings Way, Worcester WR5 1DD, UK.ORCID 0000-0002-7584-1838
Edward J DickensonUniversity Hospitals of Coventry & Warwickshire NHS Trust, Clifford Bridge Road, Coventry CV2 2DX, UK.ORCID 0000-0001-8369-1262
Kashif RajpootSchool of Computer Science, University of Birmingham Dubai, Dubai International Academic City, Dubai P.O. Box 341799, United Arab Emirates.
Mingzhan XueQatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha P.O. Box 34110, Qatar.ORCID 0000-0001-9184-2980
Essam M AbdelalimQatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha P.O. Box 34110, Qatar.ORCID 0000-0001-7764-6772
Abdelilah ArredouaniQatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha P.O. Box 34110, Qatar.ORCID 0000-0002-5060-916X
Omar M E AlbaghaQatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha P.O. Box 34110, Qatar.ORCID 0000-0001-5916-5983
Damian R GriffinUniversity Hospitals of Coventry & Warwickshire NHS Trust, Clifford Bridge Road, Coventry CV2 2DX, UK.ORCID 0000-0003-0952-7848
Paul J ThornalleyQatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha P.O. Box 34110, Qatar.ORCID 0000-0001-7659-443X
Naila RabbaniDepartment of Basic Medical Science, College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0002-5819-2506

Funding

Qatar University High Impact Award QUHIG-CMED-2021/22-1University of Warwick Impact Fund 35036Val Smith Legacy Award no 155
6 · The paper itself

Abstract

The diagnosis of early-stage osteoarthritis (eOA) is important in disease management and outcomes. Herein we report the clinical validation of a blood test for the diagnosis of eOA in a large patient cohort using trace-level glycated and oxidized amino acid analytes. Subjects were recruited and enrolled in two study groups: subjects with eOA of the hip (n = 110) and asymptomatic controls (n = 120). Their plasma was analyzed for glycated and oxidized amino acids by quantitative liquid chromatography-tandem mass spectrometry. Algorithms were developed using plasma hydroxyproline and 12 glycated and oxidized amino acid analyte features to classify the subjects with eOA and asymptomatic controls. The accuracy was defined as the percentage of the subjects correctly classified in the test set validation. The minimum number of analyte features required for the optimum accuracy was five glycated amino acid analytes: N

Indexed as

glycationmachine learningosteoarthritisoxidative stress

Identifiers

PMID41154455
PMCPMC12561690

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.