Evidence map›Paper›PMID 41154418›Full record

ArticleCancers2025

Molecular Characterization of Seminoma Utilizing the AACR Project GENIE: A Retrospective Observational Study.

Suchit R Geereddy, Amber Chang, Alma Gallegos, Jonathan Lin, Akaash Surendra, Suraj Puvvadi, Beau Hsia, Abubakar Tauseef, Joseph Thirumalareddy, Akshat Sood

Abstract read
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In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Suchit R GeereddyCollege of Biological Sciences, University of California-Davis, Davis, CA 95616, USA.
Amber ChangCollege of Medicine, University of South Florida Health Morsani, Tampa, FL 33602, USA.
Alma GallegosCollege of Biological Sciences, University of California-Davis, Davis, CA 95616, USA.
Jonathan LinCollege of Arts and Sciences, Santa Clara University, Santa Clara, CA 95053, USA.ORCID 0009-0005-5510-7686
Akaash SurendraDepartment of Medicine, Arizona State University, Tempe, AZ 85281, USA.ORCID 0009-0006-9693-4829
Suraj PuvvadiDepartment of Medicine, Arizona State University, Tempe, AZ 85281, USA.ORCID 0009-0001-2588-7942
Beau HsiaSchool of Medicine, Creighton University, Phoenix Campus, Phoenix, AZ 85012, USA.
Abubakar TauseefSchool of Medicine, Creighton University, Ohama Campus, Ohama, NE 68124, USA.
Joseph ThirumalareddySchool of Medicine, Creighton University, Ohama Campus, Ohama, NE 68124, USA.
Akshat SoodSchool of Medicine, Creighton University, Ohama Campus, Ohama, NE 68124, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeminoma is a malignant germ cell tumor that most commonly involves the testicles but may involve the mediastinum, the retroperitoneum, and other extra-gonadal sites as well. This study aims to investigate the somatic genomic landscape of seminoma.

methodsData for a retrospective observational analysis of seminoma was acquired from the American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) with clinical and genomic data from 2017 and beyond. Using the R and R Studio software (R 4.5.0), analyses for common somatic mutations and copy number alterations were run with a statistical significance of

resultsThe most mutated genes included

conclusionsThis study provided a comprehensive molecular and genetic profiling of seminoma including key genetic alterations, affected pathways, and potential therapeutic strategies. Moreover, overlap between pathways and gene mutations provides the potential for alternative treatment options for seminoma via multiple pathways.

Indexed as

AACR project GENIEbiomarker discoverycancer genomicsKIT/RAS/MAPKPI3K/AKT/mTORseminomasomatic mutationstargeted therapy

Identifiers

PMID41154418
PMCPMC12562549

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.