ArticleCancers2025
From TNM 8 to TNM 9: Stage Migration and Histology-Specific Patterns in Lung Cancer.
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Determinants of Pneumothorax and Alveolar Hemorrhage After CT-Guided Lung Biopsy.Diagnostics (Basel, Switzerland) · 2026Article
- Machine Learning-Derived Risk Groups and Clinical Implementation of Survival Prediction in Lung Cancer: Evidence from a Kazakh National Cohort.Diagnostics (Basel, Switzerland) · 2026Article
- Survival impact of pN2a and pN2b nodal status in stage IIB-IIIB non-small cell lung cancer under the 9Turk gogus kalp damar cerrahisi dergisi · 2026Article
- Prognostic factors in early-stage lung adenocarcinoma: a multicenter study prognostic markers in early lung adenocarcinoma.Journal of cardiothoracic surgery · 2026Article
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10 authors.
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Abstract
introductionThe 9th edition of the TNM classification for lung cancer implemented significant revisions, notably the subdivision of the N2 and M1c categories, to enhance anatomical precision and prognostic accuracy. Nonetheless, the actual effects of these modifications on stage distribution, histology-specific patterns, and clinical interpretation remain to be fully evaluated.
objectivesTo compare lung cancer staging distributions between the 8th and 9th TNM editions, analyze patterns of stage migration, and evaluate histology-specific reclassification trends. Although TNM 9 applies the same descriptors across all histological subtypes, the magnitude of stage migration varies. In our cohort and in international datasets, adenocarcinoma demonstrated a higher likelihood of reclassification into advanced stages compared to other subtypes.
methodsA retrospective analysis was performed on a cohort of lung cancer patients staged according to the 8th and 9th editions of the TNM classification. Stage distribution alterations were analyzed by chi-squared tests, whereas McNemar's test examined the directional shifts in upstaging and downstaging. Further investigations evaluated the correlation between histological subtype and stage reclassification.
resultsA statistically significant redistribution of stages was noted (χ
conclusionsThe 9th edition of the TNM classification results in significant stage migration, particularly in adenocarcinoma cases, indicating the improved sensitivity of the updated criteria in identifying advanced nodal disease. These modifications significantly impact prognostic evaluation and global comparability of clinical cohorts, supporting the implementation of TNM 9 as a more anatomically and biologically relevant staging system.
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