ArticleBrain sciences2025
Collateral Status Evaluation Using CT Angiography and Perfusion Source Images in Acute Stroke Patients.
Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Venous-phase Tan-based collateral assessment on CTP-derived CTA for outcome stratification after reperfusion therapy in acute ischemic stroke.Frontiers in neurology · 2026Article
- Collateral status predicts functional outcome in early-treated large-core anterior circulation stroke.Frontiers in stroke · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND/
objectivesSingle-phase CT angiography (sCTA) is widely used to assess collateral circulation in acute ischemic stroke, but its static nature can lead to an underestimation of collateral flow. Our study aimed to develop and validate a direct, qualitative dynamic CTA (dCTA) collateral score based on CTP source images, without the need for post-processing software, to provide a more accurate prognostic tool.
methodsWe retrospectively analyzed 112 patients with anterior circulation ischemic stroke from a prospective registry who underwent non-contrast CT, sCTA, and CTP within 8 h of onset. Collateral circulation was graded using a 4-point sCTA score and our novel 4-point dCTA score, which incorporates temporal filling patterns. We used linear regression to compare the association of both scores with CTP-derived core/hypoperfusion volumes, infarct growth, and final infarct volume.
resultsThe dCTA method frequently reclassified patients with poor collaterals on sCTA to good collaterals on dCTA (
conclusionsA collateral score derived from CTP source images (dCTA) offers a more reliable prediction of infarct lesion sizes and progression than conventional sCTA. By incorporating temporal resolution without requiring extra software, dCTA provides a robust correlation with stroke temporal evolution and represents a readily implementable tool to enhance patient selection in acute stroke.
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