Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Jadier Colón-VázquezDepartment of Biochemistry, School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA.ORCID 0000-0003-3859-9680
Nathaly M Rosado-RiveraDepartment of Biochemistry and Molecular Biology, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Joshua J Navedo-JacksonDepartment of Biochemistry, School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA.
Arelys A Angueira-LaureanoDepartment of Medicine, School of Medicine, University of Puerto Rico, Medical Science Campus, San Juan, PR 0093, USA.
Yanitza Hernandez-SantiagoDepartment of Biochemistry, School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA.
Geronimo Maldonado-MartinezComprehensive Cancer Center, University of Puerto Rico, San Juan, PR 00921, USA.ORCID 0000-0002-6859-0866
Miguel P Méndez-GonzálezNatural Sciences Department, University of Puerto Rico, Aguadilla, PR 00603, USA.ORCID 0000-0003-0079-4042
Misty J EatonDepartment of Biochemistry, School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA.
Serguei N SkatchkovDepartment of Biochemistry, School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA.
David E Rivera-AponteDepartment of Biochemistry, School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA.
Funding
SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Jose R. Rodriguez-Medina · 2012 to 2026
$52.9M
UNIVERSIDAD CENTRAL DEL CARIBE BIOMEDICAL RESEARCH CENTERSG12MD007583 · NIMHD · UNIVERSIDAD CENTRAL DEL CARIBE · PI RODRIGUEZ, JOSE GINEL · 2012 to 2016
$8.4M
Preparing Future Faculty: RISEing to the ChallengeR25GM110513 · NIGMS · UNIVERSIDAD CENTRAL DEL CARIBE · PI RIVERA, DAVID E. · 2014 to 2023
$2.4M
Polyamines and Brain SignalingR01NS065201 · NINDS · UNIVERSIDAD CENTRAL DEL CARIBE · PI SKATCHKOV, SERGUEI N · 2010 to 2013
$1.3M
Glial Cells and Polyamine Signaling in the Central Nervous SystemR15NS116478 · NINDS · UNIVERSIDAD CENTRAL DEL CARIBE · PI SKATCHKOV, SERGUEI N · 2020 to 2024
$900k
Hippocampal astrocytic Kir4.1 channel function in Type 2 diabetic mice: impact on neuronal hyperexcitabilitySC2NS124907 · NINDS · UNIVERSITY OF PUERTO RICO AT AGUADILLA · PI MENDEZ, MIGUEL P · 2021 to 2023
objectivesDiabetes mellitus is a metabolic disorder, and hyperglycemia results in abnormal brain function. Since glycolysis is the main energy pathway in glial cells, astrocytes possess a more developed glyoxalase (Glo) system than neurons and exhibit better survival. Glycolysis helps to protect glia from (i) dicarbonyl stress and (ii) formation of advanced glycation end products (AGEs). Since aminoguanidine (AG) is an inhibitor of AGE production, the purpose of this study was to determine the role of AG in crucial astrocytic proteins, such as Kir4.1, Glo1, and Glo2, in hyperglycemic conditions.
methodsWe cultured astrocytes in normal (5 mM)- and high (25 mM)-glucose conditions. After two weeks, we seeded the cells in six-well plates, with 300,000 cells/well, and then treated them with 9 mM of AG for 24 h.
resultsExpression of the glyoxalases Glo1 and Glo2, and of Kir4.1, is decreased in hyperglycemic conditions; however, treatment with AG recovers the expression of the Kir4.1 protein as well as the inward currents of hyperglycemic astrocytes.
conclusionWe demonstrated that regulation of the glyoxalase system via AG or another scavenger of carbonyl and aldehydes containing polyamine groups can contribute to the recovery of astrocyte function in diabetic patients.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Role of Glyoxalase in Astrocytes' Supportive Function Under Hyperglycemic Conditions: Aminoguanidine and Kir4.1 Channel Recovery. · full record | OpenQuestion