Evidence map›Paper›PMID 41154134›Full record

ReviewBrain sciences2025

Artificial Intelligence in PET Imaging for Alzheimer's Disease: A Narrative Review.

Andrea Marongiu, Angela Spanu, Barbara Palumbo, Francesco Bianconi, Luca Filippi, Giuseppe Madeddu, Susanna Nuvoli

Abstract readReview
In one paragraph

Review in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrea MarongiuUnit of Nuclear Medicine, Department of Medicine, Surgery and Pharmacy, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy.ORCID 0000-0001-7038-3615
Angela SpanuUnit of Nuclear Medicine, Department of Medicine, Surgery and Pharmacy, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy.ORCID 0000-0001-5753-399X
Barbara PalumboSection of Nuclear Medicine and Health Physics, Department of Medicine and Surgery, Università degli Studi di Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy.
Francesco BianconiDepartment of Engineering, Università degli Studi di Perugia, Via Goffredo Duranti 93, 06125 Perugia, Italy.ORCID 0000-0003-3371-1928
Luca FilippiDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0003-4423-5496
Giuseppe MadedduUnit of Nuclear Medicine, Department of Medicine, Surgery and Pharmacy, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy.
Susanna NuvoliUnit of Nuclear Medicine, Department of Medicine, Surgery and Pharmacy, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy.ORCID 0000-0002-7194-985X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid advancements in computer processing, algorithmic development, and the availability of large-scale datasets have positioned Artificial Intelligence (AI) as a valuable tool across multiple domains, including Medicine. In the field of Nuclear Medicine neuroimaging, with Positron Emission Tomography (PET), AI has demonstrated significant potential in improving diagnostic accuracy for neurodegenerative cognitive disorders. This is especially relevant for the early diagnosis, preclinical detection, and prediction of disease progression in Alzheimer's disease (AD), the most prevalent form of cognitive impairment in individuals over 65 years of age. This narrative review aims to synthesize current advances, explore future directions, and highlight outstanding challenges in the application of Artificial Intelligence to PET imaging for the clinical management of Alzheimer's disease, with particular focus on three key modalities:

Indexed as

18F-FDG PETAlzheimer’s diseaseAmyloid PETArtificial IntelligenceTau PET

Identifiers

PMID41154134
PMCPMC12564373

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.