An Optimized Chickpea Protein Hydrolysate Exerts Long-Term Antihypertensive Effects and Upregulates ACE2 and Mas1 Gene Expression in Spontaneously Hypertensive Rats.

Oscar Gerardo Figueroa-Salcido, Jesús Gilberto Arámburo-Gálvez, Lilian Karem Flores-Mendoza, Giovanni I Ramírez-Torres, Martina Hilda Gracia-Valenzuela, Edith Oliva Cuevas-Rodríguez, Noé Ontiveros

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Oscar Gerardo Figueroa-SalcidoIntegral Postgraduate Program in Biotechnology, Faculty of Chemical and Biological Sciences, Autonomous University of Sinaloa, Ciudad Universitaria, Culiacán 80010, Sinaloa, Mexico.ORCID 0000-0003-4276-8715

Jesús Gilberto Arámburo-GálvezFaculty of Nutrition and Gastronomy Sciences, Autonomous University of Sinaloa, Ciudad Universitaria, Culiacán 80010, Sinaloa, Mexico.ORCID 0000-0002-6977-5651

Lilian Karem Flores-MendozaClinical and Research Laboratory (LACIUS, C.N., CONAHCYT National Laboratory, LANIBIOC), Department of Chemical, Biological, and Agricultural Sciences (DC-QB), Faculty of Biological and Health Sciences, University of Sonora, Navojoa 85880, Sonora, Mexico.ORCID 0000-0002-6490-1364

Giovanni I Ramírez-TorresFaculty of Physical Education and Sports, University of Sinaloa, Culiacan 80013, Sinaloa, Mexico.ORCID 0000-0001-6418-6519

Martina Hilda Gracia-ValenzuelaLaboratory for the Research and Detection of Biological Agents and Contaminants (CONAHCYT National Laboratory, LANIBIOC), Instituto Tecnológico del Valle del Yaqui, Tecnológico Nacional de México, Av. Tecnológico, Block 611, Bácum 82276, Sonora, Mexico.

Edith Oliva Cuevas-RodríguezIntegral Postgraduate Program in Biotechnology, Faculty of Chemical and Biological Sciences, Autonomous University of Sinaloa, Ciudad Universitaria, Culiacán 80010, Sinaloa, Mexico.ORCID 0000-0001-6648-7323

Noé OntiverosClinical and Research Laboratory (LACIUS, C.N., CONAHCYT National Laboratory, LANIBIOC), Department of Chemical, Biological, and Agricultural Sciences (DC-QB), Faculty of Biological and Health Sciences, University of Sonora, Navojoa 85880, Sonora, Mexico.ORCID 0000-0001-8678-0447

Funding

Universidad de Sonora USO513009049

6 · The paper itself

Abstract

Chickpea protein hydrolysates have antihypertensive potential. However, neither the effect of their daily consumption on blood pressure (BP) nor their potential antihypertensive mechanisms has been evaluated. Thus, both the antihypertensive effect of an optimized chickpea protein hydrolysate (OCPH) and its potential mechanisms were assessed in spontaneously hypertensive rats. OCPH (50 mg/kg of body weight) was supplemented daily (5 weeks), BP levels were measured, and mRNA relative levels (angiotensin-converting enzyme-I (ACE1), renin, AT

Indexed as

ACE1ACE2antihypertensivebioactive peptideschickpeahypertensionSHR

Identifiers

PMID41154073

DOI10.3390/foods14203537

PMCPMC12564324

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.