Evidence map›Paper›PMID 41153724›Full record

ArticleBiomedicines2025

Cyclophilin Inhibitor Rencofilstat Combined with Proteasome Inhibitor Ixazomib Increases Proteotoxic Cell Death in Advanced Prostate Cancer Cells with Minimal Effects on Non-Cancer Cells.

Carlos Perez-Stable, Alicia de Las Pozas, Medhi Wangpaichitr, Robert T Foster, Daren R Ure

Abstract read
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carlos Perez-StableResearch Service, Bruce W. Carter Veterans Affairs Medical Center, Miami, FL 33125, USA.ORCID 0000-0003-0567-9465
Alicia de Las PozasResearch Service, Bruce W. Carter Veterans Affairs Medical Center, Miami, FL 33125, USA.
Medhi WangpaichitrResearch Service, Bruce W. Carter Veterans Affairs Medical Center, Miami, FL 33125, USA.ORCID 0000-0002-7338-2041
Robert T FosterHepion Pharmaceuticals, Edmonton, AB T5J 4P6, Canada.
Daren R UreHepion Pharmaceuticals, Edmonton, AB T5J 4P6, Canada.

Funding

A New Strategy to Increase Proteotoxic Cell Death in Hepatocellular CarcinomaR03CA245780 · NCI · SOUTH FLORIDA VA FDN/RESEARCH/ EDUCATION · PI PEREZ-STABLE, CARLOS M · 2021 to 2022
$127k
Bankhead-Coley Cancer Research Program, State of Florida 8BC11BLRD VA I01 BX005051NCI NIH HHS R03 CA245780NIH HHS 1R03CA245780-22Veterans Affairs I01-BX005051
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

apoptosiscyclophilinPERKproteasomeunfolded protein responseXBP1s

Identifiers

PMID41153724
PMCPMC12561735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.