Evidence map›Paper›PMID 41153456›Full record

ArticleGenes2025

SARS-CoV-2 Infection of Lung Epithelia Leads to an Increase in the Cleavage and Translocation of RNase-III Drosha; Loss of Drosha Is Associated with a Decrease in Viral Replication.

Michael T Winters, Emily S Westemeier-Rice, Travis W Rawson, Kiran J Patel, Gabriel M Sankey, Maya Dixon-Gross, Olivia R McHugh, Nasrin Hashemipour, McKenna L Carroll, Isabella R Wilkerson and 1 more

Abstract read
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael T WintersDepartment of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0003-3532-928X
Emily S Westemeier-RiceWest Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0001-6142-8033
Travis W RawsonDepartment of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Kiran J PatelWest Virginia University School of Medicine, West Virginia University, Morgantown, WV 26506, USA.ORCID 0009-0009-7984-3126
Gabriel M SankeyDepartment of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Maya Dixon-GrossDepartment of Biology, West Virginia University, Morgantown, WV 26506, USA.
Olivia R McHughDepartment of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, West Virginia University, Morgantown, WV 26506, USA.ORCID 0009-0000-9684-4598
Nasrin HashemipourWest Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA.
McKenna L CarrollWest Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA.ORCID 0009-0007-4728-0846
Isabella R WilkersonDepartment of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Ivan MartinezDepartment of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, West Virginia University, Morgantown, WV 26506, USA.

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI Trupti Joshi · 2012 to 2026
$61.1M
WVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Karen H Martin · 2018 to 2026
$22.4M
Construction of New Animal Facility Annex for West Virginia UniversityC06RR030016 · NCRR · WEST VIRGINIA UNIVERSITY · PI DILLON, GLENN H · 2010 to 2010
$14.6M
VS-CoBRE Administrative CoreP20GM144230 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Visvanathan Ramamurthy · 2022 to 2026
$13.9M
American Cancer Society RSG-24-1039619-01-RMCNCRR NIH HHS C06 RR030016NIGMS NIH HHS 5U54GM104942-03NIGMS NIH HHS P20 GM103434NIGMS NIH HHS P20 GM121322NIGMS NIH HHS P20 GM144230NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19LungRibonuclease IIISARS-CoV-2Virus ReplicationCell LineEpithelial CellsHumansDROSHA protein, humanRibonuclease IIIcoronavirusCOVID-19host defensemiRNA biogenesispathogenic mechanismRNase-III DroshaSARS-CoV-2

Identifiers

PMID41153456
PMCPMC12564117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.