Evidence map›Paper›PMID 41153443›Full record

ArticleGenes2025

Analysis of Semen Proteomic Differences Among Three Genotypes of FecB Rams in Duolang Sheep.

Yanlong Zhang, Zhigang Niu, Jiabao Yan, Yang Chen, Zhengfen Xue, Jie Xu, Yifan Ma, Hongcai Shi

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In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yanlong ZhangCollege of Animal Science and Technology, Xinjiang Agricultural University, Urumqi 830052, China.
Zhigang NiuXinjiang Key Laboratory of Animal Biotechnology, Key Laboratory of Herbivorous Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, Institute of Biotechnology, Xinjiang Academy of Animal Sciences, Urumqi 830011, China.ORCID 0000-0003-3570-8490
Jiabao YanCollege of Animal Science and Technology, Xinjiang Agricultural University, Urumqi 830052, China.
Yang ChenCollege of Animal Science and Technology, Shihezi University, Shihezi 832061, China.
Zhengfen XueXinjiang Key Laboratory of Animal Biotechnology, Key Laboratory of Herbivorous Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, Institute of Biotechnology, Xinjiang Academy of Animal Sciences, Urumqi 830011, China.
Jie XuCollege of Animal Science and Technology, Xinjiang Agricultural University, Urumqi 830052, China.
Yifan MaCollege of Animal Science and Technology, Xinjiang Agricultural University, Urumqi 830052, China.
Hongcai ShiXinjiang Key Laboratory of Animal Biotechnology, Key Laboratory of Herbivorous Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, Institute of Biotechnology, Xinjiang Academy of Animal Sciences, Urumqi 830011, China.

Funding

shihongcai 2023A02004
6 · The paper itself

Abstract

backgroudsTo explore the differences in semen proteins among rams of three

methodsThis study employed DIA quantitative proteomics technology to identify semen proteins from four wild-type (Group A), two heterozygous (Group B), and three homozygous (Group C) rams.

resultsCompared with the ++ genotype, the differentially expressed proteins (DEPs) in the semen of B+ genotype rams are significantly involved in the biological process of innate immune response and are significantly enriched in the oxidative phosphorylation pathway in KEGG analysis. From a biological perspective, the innate immune response may affect the immune health of Duolang sheep, while oxidative phosphorylation influences energy metabolism, which in turn impacts reproductive performance. Compared with the BB genotype, the DEPs in the semen of B+ genotype rams participate in biological processes such as protein phosphorylation and protein hydrolysis during cellular protein catabolism. These DEPs are also significantly enriched in pathways related to Parkinson's disease and non-alcoholic fatty liver disease in KEGG analysis. These differences may affect the cellular metabolism and physiological functions of Duolang sheep, thereby being associated with their reproductive performance. Compared with the ++ genotype, the DEPs in the semen of BB genotype rams exhibit differences in molecular function, cellular component, KEGG pathway, domain function, and subcellular localization. For instance, they are involved in threonine-type endopeptidase activity and associated with pathways like Alzheimer's disease and retrograde endocannabinoid signaling.

conclusionsThese differences may have potential impacts on the physiology and reproductive performance of Duolang sheep.

Indexed as

ProteomeSemenAnimalsGenotypeMaleProteomicsSheepProteomeDuolang sheepFecBproteomicssemen

Identifiers

PMID41153443
PMCPMC12562352

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.