ArticleGenes2025
Genome-Wide Association Study of Morphological Defects in Nellore Cattle Using a Binary Trait Framework.
Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Congenital central nervous system malformations in piedmontese calves-part 1. structural brain disorders.Frontiers in veterinary science · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesMorphological defects such as limb malformations, cranial asymmetries, loin deviations, jaw misalignments, and navel irregularities are associated with early culling and reduced productivity in beef cattle. In
methodsDepending on the trait, the number of genotyped animals analyzed ranged from 3369 to 23,206, using 385,079 SNPs (after quality control). Analyses were conducted using a linear mixed model framework adapted for binary outcomes.
resultsSignificant associations were identified for four traits: feet and legs, chamfer, hump, and loin. No significant markers were detected for jaw or navel defects, likely due to lower sample sizes and trait incidence. Gene annotation revealed 49 candidate genes related to feet and legs, 4 for chamfer, 4 for hump, and 6 for loin.
conclusionsCandidate genes were enriched for biological functions, including bone remodeling, muscle development, lipid metabolism, and epithelial organization. Overlaps with QTL related to conformation, feed intake, reproductive traits, and carcass quality were also observed. These findings provide novel insights into the genetic control of morphological defects in Nellore cattle and may inform breeding strategies aimed at improving structural soundness.
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