Genetic Variability in NKG2 Receptors and Their Ligands: Associations with SARS-CoV-2 Infection and COVID-19 Severity.

Jagoda Siemaszko, Katarzyna Grad, Jerzy Świerkot, Katarzyna Bogunia-Kubik

Abstract read

In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Jagoda SiemaszkoLaboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.ORCID 0000-0002-4440-1709

Katarzyna GradLaboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.

Jerzy ŚwierkotDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland.

Katarzyna Bogunia-KubikLaboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.

Funding

Wroclaw Medical University SUBZ.A270.23.062

6 · The paper itself

Abstract

backgroundThe emergence of the COVID-19 pandemic has accelerated research into diverse immune response mechanisms. One key area of interest is the regulation of cytotoxic activity by Natural Killer (NK) cells. These cells rely on a dynamic interplay between activating and inhibitory surface receptors that recognize specific ligands on target cells. Among these, receptors from the NKG2 family are particularly important, as maintaining their proper balance and function is essential for controlling NK cell cytotoxicity.

methodsIn this study we employed qPCR to assess the genetic variability using single-nucleotide polymorphisms (SNPs) of NKG2A and NKG2D receptors and their ligands HLA-E and MICA/MICB. NKG2C deletion was determined by PCR-SSP, and serum-soluble levels of HLA-E and MICA/MICB molecules were measured by ELISA and Luminex methods.

resultsGenotyping studies revealed that both

conclusionsGenetic variability of NK cell receptors and ligands as well as serum levels of their soluble forms showed associations with the risk of development of COVID-19 and the severity of its symptoms.

Indexed as

COVID-19Histocompatibility Antigens Class INK Cell Lectin-Like Receptor Subfamily CAdultAgedFemaleGenetic Predisposition to DiseaseHLA-E AntigensHumansKiller Cells, NaturalLigandsMaleMiddle AgedNK Cell Lectin-Like Receptor Subfamily KPolymorphism, Single NucleotideSARS-CoV-2Histocompatibility Antigens Class IHLA-E AntigensKLRC1 protein, humanLigandsMHC class I-related chain ANK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily KCOVID-19HLA-ENK cell receptorsNK cellsNKG2CSARS-CoV-2viral infection

Identifiers

PMID41153412

DOI10.3390/genes16101193

PMCPMC12564355

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