Evidence map›Paper›PMID 41153387›Full record

ArticleGenes2025

Transcriptomic and Clinical Profiling Reveals

Grazia Scuderi, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michelino Di Rosa, José Francisco Muñoz-Valle, Alexis Missael Vizcaíno-Quirarte, Gian Marco Leone, Katia Mangano, Paolo Fagone, Ferdinando Nicoletti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Grazia ScuderiDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Sanja MijatovicDepartment of Immunology, Institute for Biological Research "Sinisa Stankovic", Belgrade University, 11060 Belgrade, Serbia.ORCID 0000-0001-9509-9098
Danijela Maksimovic-IvanicDepartment of Immunology, Institute for Biological Research "Sinisa Stankovic", Belgrade University, 11060 Belgrade, Serbia.ORCID 0000-0002-8006-5079
Michelino Di RosaDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-1837-9325
José Francisco Muñoz-ValleDepartment of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-2272-9260
Alexis Missael Vizcaíno-QuirarteDepartment of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0009-0005-2443-0210
Gian Marco LeoneDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-8593-6179
Katia ManganoDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-5920-4620
Paolo FagoneDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-6694-1992
Ferdinando NicolettiDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-4570-8462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesGalectin-3 (Gal-3), encoded by

methodsWe analyzed CRISPR-Cas9 knockout transcriptomic data from the SigCom LINCS database to characterize the consensus gene signature associated with

results

conclusionsThese findings identify Galectin-3 as a key regulator of oncogenic programs and a potential prognostic biomarker in PDAC and other malignancies, with implications for therapeutic targeting.

Indexed as

Biomarkers, TumorCarcinoma, Pancreatic DuctalGalectin 3OncogenesPancreatic NeoplasmsTranscriptomeBlood ProteinsCell Line, TumorGalectinsGene Expression ProfilingGene Expression Regulation, NeoplasticHumansPrognosisBiomarkers, TumorBlood ProteinsGalectin 3GalectinsLGALS3 protein, humangalectinsLGALS3prognostic biomarkertranscriptomics

Identifiers

PMID41153387
PMCPMC12562417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.