Evidence map›Paper›PMID 41153375›Full record

ArticleGenes2025

Casparian Strip Fortification as a Defense Mechanism to

Stephen Parris, Sonika Kumar, Zhigang Li, Jim Olvey, Mike Olvey, Don C Jones, Christopher A Saski

Abstract read
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephen ParrisDepartment of Plant and Environmental Sciences, Clemson University, Clemson, SC 29634, USA.
Sonika KumarDepartment of Plant and Environmental Sciences, Clemson University, Clemson, SC 29634, USA.ORCID 0009-0000-7088-2844
Zhigang LiDepartment of Plant and Environmental Sciences, Clemson University, Clemson, SC 29634, USA.
Jim OlveyO&A Enterprises, Maricopa, AZ 85139, USA.
Mike OlveyO&A Enterprises, Maricopa, AZ 85139, USA.
Don C JonesCotton Incorporated, Cary, NC 27513, USA.ORCID 0000-0001-8391-004X
Christopher A SaskiDepartment of Plant and Environmental Sciences, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0002-2780-4274

Funding

Regulation of Cryptosporidium DevelopmentP20GM146584 · NIGMS · CLEMSON UNIVERSITY · PI KERRY Scot SMITH · 2022 to 2026
$13.5M
Statistical Methods for Gene Regulatory Analysis From Single Cell Genomics DataP20GM139769 · NIGMS · CLEMSON UNIVERSITY · PI ANHOLT, ROBERT R. H, ARNO, GAVIN · 2021 to 2025
$10.8M
Cotton Incorporated 19-860Foundation for Food and Agriculture Research 23-000853National Institute of Food and Agriculture 2019-67029 and 2021-11395NIGMS NIH HHS P20 GM139769NIGMS NIH HHS P20 GM146584
6 · The paper itself

Abstract

BACKGROUND/

objectivesFusarium wilt of cotton, caused by

methodsWe conducted an in vitro infection assay using two

resultsResistant plants 'DP348RF' showed strong induction of genes related to reactive oxygen species (ROS) metabolism, chitinase activity, and lignification compared to the susceptible cultivar. Notably, genes involved in the biosynthesis and reinforcement of the Casparian strip, a critical biochemical barrier limiting pathogen penetration into vascular tissues, were uniquely and significantly upregulated in resistant roots. These transcriptional responses suggest that fortification of cell wall barriers and enhanced antimicrobial defenses contribute to effective restriction of FOV4 colonization.

conclusionsOur findings identify a distinct molecular signature of resistance to FOV4 in pima cotton, with Casparian strip reinforcement emerging as a potential mechanism limiting vascular infection. These insights provide a foundation for breeding strategies aimed at improving Fusarium wilt resistance in cotton.

Indexed as

Disease ResistanceFusariumGossypiumPlant DiseasesGene Expression Regulation, PlantPlant ProteinsPlant RootsTranscriptomePlant Proteinscasparian stripfusarium wilt race 4pima cottontranscriptomics

Identifiers

PMID41153375
PMCPMC12563867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.