Lack of Association Between COL1A1 rs1800012 Polymorphism and Anterior Open Bite Malocclusion in a Turkish Case-Control Cohort.

Tolga Polat, Özlem Özge Yılmaz, Elvan Önem Özbilen, Beste Tacal Aslan

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Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Tolga PolatDepartment of Basic Medical Sciences, Faculty of Dentistry, Marmara University, 34854 Istanbul, Türkiye.ORCID 0000-0002-2064-6613

Özlem Özge YılmazDepartment of Basic Medical Sciences, Faculty of Dentistry, Marmara University, 34854 Istanbul, Türkiye.ORCID 0000-0002-4085-6159

Elvan Önem ÖzbilenDepartment of Orthodontics, Faculty of Dentistry, Marmara University, 34854 Istanbul, Türkiye.ORCID 0000-0002-5052-2320

Beste Tacal AslanDepartment of Basic Medical Sciences, Faculty of Dentistry, Marmara University, 34854 Istanbul, Türkiye.ORCID 0000-0001-5271-7917

Funding

Marmara University Project code: 10935

6 · The paper itself

Abstract

BACKGROUND/

objectivesAnterior open bite is a multifact orial malocclusion influenced by genetic and environmental factors. Variants in the Collagen type I, alpha 1 (

methodsA case-control study was conducted with 60 participants (30 anterior open bite cases; 30 matched controls). DNA was extracted from buccal swabs, and rs1800012 genotyping was performed using TaqMan assays. Genotype and allele distributions were compared with chi-square and Fisher's exact tests; Hardy-Weinberg equilibrium was assessed in controls.

resultsGenotype (GG/GT/TT: 53.3/40.0/6.7% vs. 60.0/33.3/6.7%) and allele (T allele: 26.7% vs. 23.3%) frequencies did not differ significantly between cases and controls. No association was detected under additive, dominant, or recessive models (all

conclusionsThis study provides no evidence of association between

Indexed as

Collagen Type IOpen BitePolymorphism, Single NucleotideAdolescentAdultAllelesCase-Control StudiesCollagen Type I, alpha 1 ChainFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleTurkeyYoung AdultCOL1A1 protein, humanCollagen Type ICollagen Type I, alpha 1 ChainCOL1A1geneticgenetic polymorphismmalocclusionopen bite

Identifiers

PMID41153339

DOI10.3390/genes16101122

PMCPMC12562384

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