ArticleEuropean journal of medical research2025
The association of thyroid peroxidase antibodies with microvascular invasion in patients with papillary thyroid carcinoma.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purposePapillary Thyroid Carcinoma (PTC) is the most prevalent thyroid malignancy. Current evidence on the association between thyroid peroxidase antibody (TPOAB) levels and microvascular invasion (MVI) in PTC is limited. The aim of this study was to investigate the association between TPOAB and MVI in patients with PTC.
methodsThis retrospective study included patients with PTC who underwent surgery at the First People's Hospital of Zunyi between May 22, 2022, and March 06, 2024. Preoperative TPOAB levels were recorded, along with several potential confounding factors, including sex, age, BMI, smoking, drinking, tumor size, multiple foci, thyroglobulin antibody (TGAB), thyroglobulin (Tg) and preoperative thyroid function. TPOAB levels were log-transformed and denoted as lnTPOAB for analysis. MVI was determined based on the postoperative pathology reports. Multivariable logistic regression analysis was conducted to investigate the association between lnTPOAB and MVI risk, adjusted for confounding factors. A restricted cubic spline model was employed to examine the nonlinear relationship between ln TPOAB and MVI. The inflection point was calculated using a two-piece linear-regression model. Subgroup analyses were performed to verify the association between TPOAB and MVI.
resultsA total of 409 participants were included in the study. In the multivariable logistic regression model, after adjusting for all potentially confounding variables, the odds ratio (95% confidence interval) of lnTPOAB associated with MVI was 1.18 (1.03, 1.34; P = 0.013). The restricted cubic spline demonstrated a non-linear association between lnTPOAB and MVI. The two-piecewise regression model indicated that the inflection point was - 1.1, corresponding to a raw estimate of TPOAB of 0.33 IU/ml. Subgroup analyses further validated the positive association between TPOAB levels and MVI in patients with PTC.
conclusionsElevated TPOAb levels were independently associated with higher odds of MVI. Therefore, TPOAb may act as a supportive preoperative risk marker, helping to guide the extent of surgery and, together with tumor size and biochemical markers, customize early postoperative follow-up strategies. However, its clinical value still requires confirmation in prospective studies.
trial registrationChiCTR2400084886, date of registration: May 27, 2024, retrospectively registered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.