ArticleJournal of anesthesia, analgesia and critical care2025
The influence of thirty-degree leg elevation on noradrenaline requirements administered as a prophylactic variable infusion during cesarean delivery, an open-label randomized controlled trial.
Article in Journal of anesthesia, analgesia and critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06822699 (The Influence of Thirty-degree Leg Elevation on Noradrenaline Requirements Administered as a Prophylactic Variable Infusion During Cesarean Delivery), which is not on this map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Influence of Thirty-degree Leg Elevation on Noradrenaline Requirements Administered as a Prophylactic Variable Infusion During Cesarean Delivery: An Open Label Randomized Controlled Trial
Who cites it
4 citing papers in PubMed.
- Reply to commentary on "The influence of thirty-degree leg elevation on noradrenaline requirements administered as a prophylactic variable infusion during cesarean delivery, an open-label randomized controlled trial."Journal of anesthesia, analgesia and critical care · 2026Article
- Post-spinal cesarean hypotension.Journal of anesthesia, analgesia and critical care · 2026Article
- Prediction of spinal anesthesia-induced hypotension during cesarean delivery: a narrative review.Journal of anesthesia, analgesia and critical care · 2026Review
- Caffeine before cesarean delivery: a novel preventive strategy against spinal hypotension, a double blind placebo-controlled trial.Journal of anesthesia, analgesia and critical care · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpinal anesthesia is the preferred technique for elective cesarean delivery; however, it is frequently associated with spinal anesthesia-induced hypotension. To mitigate this, prophylactic vasopressors have become a cornerstone of obstetric anesthesia practice. Despite their use, hypotension may still occur, prompting the exploration of adjunctive maneuvers to enhance hemodynamic stability and reduce vasopressor requirements. This study hypothesized that passive leg elevation would reduce the need for noradrenaline during cesarean delivery under spinal anesthesia.
methodsIn this randomized controlled trial, we evaluated the effect of 30-degree leg elevation on noradrenaline requirements. Noradrenaline was administered as a variable infusion, ranging from 0.05 to 0.14 µg/kg/min. Participants were randomly assigned to either the control group or the leg elevation group. The primary outcome was the average noradrenaline requirement in each group.
resultsA total of 80 healthy pregnant patients were included in the final analysis, with 40 patients in each group. The mean noradrenaline requirement was significantly lower in the leg elevation group compared to the control group (0.067 ± 0.01 vs. 0.079 ± 0.01 µg/kg/min, respectively; p < 0.05). Additionally, the incidence of hypotension was reduced in the leg elevation group (20%) compared to the control group (40%).
conclusionAmong healthy parturients undergoing elective cesarean section, passive leg elevation significantly reduced noradrenaline requirements and was associated with a lower incidence of hypotension. This simple maneuver may serve as a valuable adjunct to pharmacologic prophylaxis in spinal anesthesia.
trial registrationThe study was registered by the principal investigator (M. Helmy) at ClinicalTrials.gov under the identifier NCT06822699 on February 7, 2025.
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