Evidence map›Paper›PMID 41152957›Full record

ArticleTranslational neurodegeneration2025

Shared burden of ultra-rare genetic variants across a spectrum of motor neuron diseases.

Gang Wu, Wenan Chen, Joanne Wuu, Angita Jain, Jason Myers, Isabell Cordts, Evadnie Rampersaud, Jeannine M Heckmann, Melissa Nel, Volkan Granit and 21 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational neurodegeneration, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Gang WuCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA. gang.wu@stjude.org.ORCID http://orcid.org/0000-0002-1678-5864
Wenan ChenCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Joanne WuuDepartment of Neurology and ALS Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Angita JainDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Jason MyersCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Isabell CordtsDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Evadnie RampersaudCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jeannine M HeckmannDivision of Neurology, Department of Medicine and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Melissa NelNeurogenomics Lab, Department of Medicine, and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Volkan GranitDepartment of Neurology and ALS Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Jeffrey StatlandDepartment of Neurology, Medical Center, University of Kansas, Kansas City, KS, USA.
Andrea SwensonDepartment of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
John RavitsDepartment of Neurosciences, School of Medicine, University of California, San Diego, USA.
Corey T McMillanDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Lauren ElmanDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
James CaressDepartment of Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Ted M BurnsDepartment of Neurology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Erik P PioroDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.
Jaya TrivediDepartment of Neurology, UT Southwestern Medical Center, Dallas, TX, USA.
Jonathan KatzDepartment of Neurology, California Pacific Medical Center, San Francisco, CA, USA.
Carlayne JacksonDepartment of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Samuel MaiserDepartment of Neurology, Department of Neurology, Hennepin Healthcare, University of Minnesota, Minneapolis, MN, USA.
David WalkDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Yuen SoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.
Jacob L McCauleyJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Matthew C BakerDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
J Paul TaylorDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Stephan ZuchnerDepartment of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.
Rosa RademakersDepartment of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, USA.
Marka van BlitterswijkDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Michael BenatarDepartment of Neurology and ALS Center, University of Miami Miller School of Medicine, Miami, FL, USA. mbenatar@miami.edu.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
YOUTH DRUG ABUSE, ADHD, AND RELATED DISRUPTIVE DISORDERSM01RR000400 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI KOTLYAR, MICHAEL · 1985 to 2009
$33.7M
Uncovering new genes and disease modifiers for ALS and related disordersU54NS092091 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Marka Van Blitterswijk · 2014 to 2026
$19.8M
ALS Association 16-TACL-242ALS Association 17-LGCA-331FDA HHS R01 FD007630NCI NIH HHS P30 CA021765NCRR NIH HHS M01 RR000400NIH HHS U54 NS092091NINDS NIH HHS U54 NS092091Wellcome TrustWellcome Trust 226519/Z/22/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41152957
PMCPMC12570777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.