Trial reportJournal of orthopaedic surgery and research2025
The effect of mobilization with movement on pain, joint distance, effusion area, and inflammation in rheumatoid arthritis: a double-blind randomized controlled clinical trial.
Trial report in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05660629 (Comparison of the Effects of Exercise and Protective Approach in the Rheumatoid Hand and Joint Mobilization Applications on Pain, Functional Status and Quality of Life), which is not on this map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Effects of Exercise and Protective Approach in the Rheumatoid Hand and Joint Mobilization Applications on Pain, Functional Status and Quality of Life
Who cites it
2 citing papers in PubMed.
- Combined effect of underwater ultrasound and custom-made insoles in rheumatoid arthritis: a randomized controlled trial.Clinical rheumatology · 2026Trial
- The Effect of Mobilization With Movement Techniques on Pain and Range of Elbow Extension in Juvenile Idiopathic Arthritis, a Case Report.Clinical case reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEffective management of established rheumatoid arthritis emphasizes on pain relief, disease control, joint preservation, and improved function and quality of life. This trial examines the effects of mobilization with movement on joint distance, effusion area, and inflammation in patients with established rheumatoid arthritis, with interventions applied to both hands.
methodsA total of 76 participants were screened, and 21 met the inclusion criteria. Participants were randomly assigned to one of three groups: the mobilization group (MG) (n = 7), sham mobilization group (SMG) (n = 7), or control group (CG) (n = 7). The groups underwent a two-week traditional physiotherapy program. In addition, the MG received mobilization with movement (5 sessions per week, 15 min per session), while the SMG received squeeze-release application during the same period. The primary outcomes were the pre- and post-treatment comparison of pain, joint space, effusion area, and inflammation. The secondary outcomes included comparisons of hand function, dexterity, grip strength, disease activity, and quality of life. Participants were assessed at both baseline and post-treatment.
resultsImprovement in joint distance, effusion area and inflamation were greater in the MG. Joint space increased by 0.3 mm at the wrist and 0.2 mm at the MCP and PIP joints. Effusion at the PIP joint decreased by 0.04 mm², and inflammation was reduced by 50.59% at the wrist and 53.33% at the PIP joint.
conclusionsThis study demonstrated that mobilization with movement effectively increases joint space and reduces inflammation in the wrist and PIP joints, improving the quality of life. Therefore, adding mobilizations to the conventional physiotherapy program might be beneficial to improve joint distance in RA patients.
trial registrationClinical Trial Registry-NCT05660629.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.