ArticleJournal of neuroengineering and rehabilitation2025
Estimating the contribution of musculoskeletal impairments to altered gait kinematics in children with cerebral palsy using predictive simulations.
Article in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundCerebral palsy (CP) is caused by a brain lesion around birth leading to impaired motor control, bony deformities, muscle contractures, and weakness resulting in altered gait. Since the brain lesion cannot be cured, treatment aims at improving mobility. Multilevel surgery targets muscle and bony impairments but the outcome of multilevel surgery is variable and unpredictable due to our limited insight in the contribution of musculoskeletal impairments to gait alterations.
methodsHere, we used predictive simulations based on personalized musculoskeletal models to identify the contribution of musculoskeletal impairments to altered gait in eight individuals with CP scheduled for multilevel surgery. For each individual, we generated gait patterns based on eight models with different levels of personalization. We modeled muscle weakness, muscle contractures, and/or bony deformities of hip and knee and evaluated the contribution of these impairments to deviations in kinematics by comparing simulated and experimental kinematics.
resultsThe contribution of modeled musculoskeletal impairments to kinematic deficits was on average 17% and never more than 39%, in line with the limited and variable effect of multilevel surgery targeting musculoskeletal impairments. Muscle contractures had the largest effect on the predicted kinematics and their effect was magnified by bony deformities and weakness.
conclusionOur results suggest an important contribution of motor control and unmodeled musculoskeletal impairments (e.g. shank and foot deformities) to alterations in the gait pattern. Model-based simulations are a promising tool to determine the contribution of musculoskeletal impairments to alterations in gait kinematics in individuals with CP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.