ArticleBMC oral health2025
Comparison of trabecular bone structure on periapical radiographs one year after apexification with MTA and regenerative endodontic treatment: a retrospective cohort study.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate and compare periapical healing by analyzing the architecture of post-treatment trabecular bone using fractal analysis (FA) following mineral trioxide aggregate (MTA) apexification and regenerative endodontic treatment (RET), as well as to investigate the correlation between FA findings and Periapical Index (PAI).
methodsA total of 37 patients (20 treated with apexification and 17 with RET) were included in the study. All selected teeth were single-rooted maxillary anterior incisors. Patients were divided into two groups based on the treatment received: either apexification or RET. At 12-month follow-up, periapical radiographs were obtained. From the designated regions of interest (ROI) on these radiographs, fractal dimension (FD) values were calculated, and PAI assessed by two observers were recorded. The Wilcoxon test was used to assess differences in time changes between measurements. Differences between groups were evaluated using the Mann-Whitney U test. Statistical significance was set at p < 0.05.
resultsThere was a statistically significant difference between the FD of the ROI post-operatively and at follow-up in both, the apexification and the RET treatment groups (p < 0.001). No statistically significant difference was observed in the changes in FD at the 12-month follow-up between the apexification and the RET group (p > 0.05). In the apexification treatment group, a moderate negative correlation was observed between the changes in PAI and the changes in FD values (Spearman's rho = - 0.444, p = 0.049), indicating that increases in trabecular bone complexity (higher FD values) were associated with lower PAI. In contrast, in the RET group no statistically significant correlation was found between the changes in PAI and the changes in FD values (p > 0.05).
conclusionBoth MTA apexification and RET support structural bone healing in the periapical region. FA offers an objective approach for quantifying changes in trabecular bone architecture and may enhance the radiographic assessment of periapical healing when used alongside conventional methods. CLINICAL TRIAL NUMBER: Not applicable - retrospective analysis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.