Evidence map›Paper›PMID 41152816›Full record

ArticleBMC infectious diseases2025

Genetic diversity and population structures of Plasmodium falciparum parasites imported to China from Central and West Africa determined using a SNP barcode.

Weilin Zeng, Wenya Zhu, Yucheng Qin, Hongyu Lan, Yulin Cen, Kemin Sun, Yiman Wu, Tao Liang, Ye Mou, Cheng Liu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Weilin Zeng *Yunnan Provincial Key Laboratory of Public Health and Biosafety & Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China.
Wenya Zhu *Yunnan Provincial Key Laboratory of Public Health and Biosafety & Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China.
Yucheng Qin *Chinese Center for Tropical Diseases Research - Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Clinical Research Alliance for Parasitic Diseases Related Infectious Diseases & Department of Infectious Diseases, Shanglin County People's Hospital, Nanning, China.
Hongyu LanChinese Center for Tropical Diseases Research - Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Clinical Research Alliance for Parasitic Diseases Related Infectious Diseases & Department of Infectious Diseases, Shanglin County People's Hospital, Nanning, China.
Yulin CenChinese Center for Tropical Diseases Research - Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Clinical Research Alliance for Parasitic Diseases Related Infectious Diseases & Department of Infectious Diseases, Shanglin County People's Hospital, Nanning, China.
Kemin SunYunnan Provincial Key Laboratory of Public Health and Biosafety & Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China.
Yiman WuYunnan Provincial Key Laboratory of Public Health and Biosafety & Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China.
Tao LiangYunnan Provincial Key Laboratory of Public Health and Biosafety & Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China.
Ye MouYunnan Provincial Key Laboratory of Public Health and Biosafety & Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China.
Cheng LiuYunnan Provincial Key Laboratory of Public Health and Biosafety & Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China.
Xiuya TangYunnan Provincial Key Laboratory of Public Health and Biosafety & Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China.
Zheng XiangYunnan Provincial Key Laboratory of Public Health and Biosafety & Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China.
Yaming HuangDepartment of Protozoan Diseases, Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Nanning, China.
Liwang CuiDivision of Infectious Diseases and International Medicine, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA. liwangcui@usf.edu.
Zhaoqing YangYunnan Provincial Key Laboratory of Public Health and Biosafety & Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China. zhaoqingy92@163.com.

Funding

National Science Foundation of China 32370543
6 · The paper itself

Abstract

backgroundMalaria remains a highly threatening infectious disease, with Africa being the main epidemic area. China has achieved the notable feat of eliminating malaria domestically, yet the looming threat of imported malaria cases remains a concern. This study aims to apply the SNP barcode technology to investigate the population structure of P. falciparum imported to China from Central and West Africa.

methodsWe applied a 24-SNP high-resolution melting (HRM) barcode to analyze the diversity of P. falciparum populations imported to China from Central and West Africa.

resultsA total of 181 samples were analyzed using HRM assay to obtain a complete 24-SNP barcode. There was no significant difference in the proportion of multi-clone infections among the four populations. The level of nucleotide diversity observed across all four populations is low. The observed pairwise F

conclusionsThe present study validated the potential of the 24-SNP HRM barcode in examining diversity and variations in imported P. falciparum populations. Our studies confirmed that this barcode is insufficient for distinguishing isolates from Central and West Africa, potentially due to the minimal genetic differentiation among P. falciparum populations in these regions.

Indexed as

Communicable Diseases, ImportedDNA Barcoding, TaxonomicGenetic VariationMalaria, FalciparumPlasmodium falciparumPolymorphism, Single NucleotideAfrica, CentralAfrica, WesternChinaHumansCentral and Western AfricaGenetic diversityPlasmodium falciparumSNP barcode

Identifiers

PMID41152816
PMCPMC12560413

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.